Katja Hönzke

TL;DR: In this article, gene expression profiles of three SARS-CoV and SARS CoV-2 infected human cell lines were reported, and it was shown that SARS co-virus infection elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS in the human epithelial cell line Calu-3, including induction of miRNA-155.

TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.

TL;DR: It is indicated that severe lung injury in COVID-19 likely results from a macrophage triggered immune activation rather than direct viral damage of the alveolar compartment, thereby limiting SARS-CoV-2 propagation and virus-induced tissue damage in the human alveolus.

TL;DR: The findings indicate that severe lung injury in COVID-19 likely results from an overwhelming immune activation rather than direct viral damage of the alveolar compartment, thereby limiting SARS-CoV-2 propagation in the human alveolus.

TL;DR: In this article, the authors used machine learning and quantitative live-cell microscopy to identify a significant number of alveolar epithelial cells surviving such executioner caspase activation after pneumolysin attack.