K
Kazuo Hara
Researcher at University of Tokyo
Publications - 240
Citations - 21491
Kazuo Hara is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 46, co-authored 201 publications receiving 20034 citations. Previous affiliations of Kazuo Hara include Tokyo Medical University.
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Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Journal ArticleDOI
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,Atsushi Tsuchida,Takehiko Yokomizo,Takehiko Yokomizo,Shunbun Kita,Takuya Sugiyama,Makoto Miyagishi,Makoto Miyagishi,Kazuo Hara,Masaki Tsunoda,Koji Murakami,Toshiaki Ohteki,S. Uchida,Sato Takekawa,Hironori Waki,Nelson H. Tsuno,Yoichi Shibata,Yasuo Terauchi,Philippe Froguel,Kazuyuki Tobe,Shigeo Koyasu,Kazunari Taira,Kazunari Taira,Toshio Kitamura,Takao Shimizu,Takao Shimizu,Ryozo Nagai,Takashi Kadowaki +29 more
TL;DR: The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Journal ArticleDOI
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
TL;DR: The pathophysiology of adiponectin and adiponECTin receptors in insulin resistance, diabetes, and the metabolic syndrome is described and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are described.
Journal ArticleDOI
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi,Yasunori Nio,Toshiyuki Maki,Masaki Kobayashi,Takeshi Takazawa,Masato Iwabu,Miki Okada-Iwabu,Sachiko Kawamoto,Naoto Kubota,Tetsuya Kubota,Yusuke Ito,Junji Kamon,Atsushi Tsuchida,Katsuyoshi Kumagai,Hideki Kozono,Yusuke Hada,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Kouji Murakami,Motoharu Awazawa,Iseki Takamoto,Philippe Froguel,Kazuo Hara,Kazuyuki Tobe,Ryozo Nagai,Kohjiro Ueki,Takashi Kadowaki +28 more
TL;DR: Adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr−/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively, and abolished adiponectin binding and actions, leading to insulin resistance and marked glucose intolerance in vivo.
Journal ArticleDOI
Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes MOLECULAR STRUCTURE AND MULTIMER FORMATION OF ADIPONECTIN
Hironori Waki,Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,S. Uchida,Shunbun Kita,Kazuo Hara,Yusuke Hada,Francis Vasseur,Philippe Froguel,Satoshi Kimura,Ryozo Nagai,Takashi Kadowaki +12 more
TL;DR: It is demonstrated that simple SDS-PAGE under non-reducing and non-heat-denaturing conditions clearly separates multimer species of adiponectin.