Roberto C. Sotero

TL;DR: Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development, suggesting early memory deficit associated with the primary disease factors.

TL;DR: In a vulnerability and betweenness centrality analysis, the most indispensable and critical anatomical areas were identified: putamens, precuneus, insulas, superior parietals and superior frontals, which suggest that even at the cost of losing in global anatomical efficiency, these structures were maintained through the evolutionary processes due to their important functions.

TL;DR: For model driven fusion, a neural mass EEG/fMRI model coupled to a metabolic hemodynamic model is formulated, and it is shown that the Local Linearization (LL) method for integrating stochastic differential equations is appropriate for highly nonlinear dynamics.

TL;DR: Simulations of human brain rhythms were carried out and Physiologically plausible results were obtained based on this anatomically constrained neural mass model, which reduces the number of connection parameters substantially in this system faster.

TL;DR: This model strongly supports the leading role of Aß clearance deficiency and early Aß onset age during Alzheimer's disease progression, and that effective anatomical distance from Aß outbreak region explains regional Aß arrival time and Aß deposition likelihood.