L
Lea K. Davis
Researcher at Vanderbilt University Medical Center
Publications - 192
Citations - 10453
Lea K. Davis is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 34, co-authored 138 publications receiving 7193 citations. Previous affiliations of Lea K. Davis include Meharry Medical College & Semel Institute for Neuroscience and Human Behavior.
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Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality
Hang Zhou,Hang Zhou,Julia M. Sealock,Sandra Sanchez-Roige,Clarke T,Daniel F. Levey,Daniel F. Levey,Zhongshan Cheng,Zhongshan Cheng,Boyang Li,Renato Polimanti,Renato Polimanti,Rachel L. Kember,Rachel L. Kember,Rachel Vickers Smith,Johan H. Thygesen,Marsha Y. Morgan,Atkinson,Mark Thursz,Mette Nyegaard,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Anders D. Børglum,Emma C. Johnson,Amy C. Justice,Amy C. Justice,Abraham A. Palmer,Andrew McQuillin,Lea K. Davis,Howard J. Edenberg,Arpana Agrawal,Henry R. Kranzler,Henry R. Kranzler,Joel Gelernter,Joel Gelernter +35 more
TL;DR: This large PAU meta-analysis identified novel risk loci and revealed genetic relationships with numerous other outcomes, including causal effects on liability to PAU of substance use, psychiatric status, risk-taking behavior, and cognitive performance.
Posted ContentDOI
Phenome-wide Investigation of Health Outcomes Associated with Genetic Predisposition to Loneliness
Abdel Abdellaoui,Sandra Sanchez-Roige,Julia Sealock,Jorien L. Treur,Jessica Dennis,Pierre Fontanillas,Sarah L. Elson,Michel G. Nivard,Hill F. Ip,Matthijs D. van der Zee,Bart M. L. Baselmans,Jouke-Jan Hottenga,Gonneke Willemsen,Miriam A. Mosing,Li Yu,Nancy L. Pedersen,Najaf Amin,Cornelia M. van Duijn,I. Szilagyi,Henning Tiemeier,Alexander Neumann,Karin J. H. Verweij,Stephanie Cacioppo,John T. Cacioppo,Lea K. Davis,Abraham A. Palmer,Dorret I. Boomsma +26 more
TL;DR: A genome-wide association meta-analysis of loneliness conducted in an independent sample of 18,498 individuals for whom electronic health records were available provided a framework for ongoing studies of the genetic basis of loneliness and its role in mental and physical health.
Posted ContentDOI
Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry
Sandra Sanchez-Roige,Pierre Fontanillas,Sarah L. Elson,Anita Pandit,Ellen M. Schmidt,Johanna Forster,Gonçalo R. Abecasis,Joshua C. Gray,Harriet de Wit,Lea K. Davis,James MacKillop,Abraham A. Palmer +11 more
TL;DR: It was shown that 12% of the variance in DD was accounted for by genotype, and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition, and body weight.
Journal ArticleDOI
Testing for association of the monoamine oxidase A promoter polymorphism with brain structure volumes in both autism and the fragile X syndrome
TL;DR: The MAOA promoter polymorphism is similarly associated with brain structure volumes in both idiopathic autism and FXS, and these data illuminate a number of important aspects of autism andFXS heritability.
Posted ContentDOI
Polygenic selection underlies evolution of human brain structure and behavioral traits
Evan R. Beiter,Ekaterina A. Khramtsova,Celia van der Merwe,Emile R. Chimusa,Corinne N. Simonti,Jason L. Stein,Paul M. Thompson,Simon E. Fisher,Simon E. Fisher,Dan J. Stein,John A. Capra,James A. Knowles,Barbara E. Stranger,Lea K. Davis +13 more
TL;DR: It is discovered that SNPs associated with some, but not all, behaviors and brain structure volumes are enriched in genomic regions under selection since divergence from Neanderthals ~600,000 years ago, and evidence for signatures of ancient and recent polygenic adaptation is shown.