L
Lea K. Davis
Researcher at Vanderbilt University Medical Center
Publications - 192
Citations - 10453
Lea K. Davis is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 34, co-authored 138 publications receiving 7193 citations. Previous affiliations of Lea K. Davis include Meharry Medical College & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems
Amanda B Zheutlin,Amanda B Zheutlin,Jessica Dennis,Richard Karlsson Linnér,Arden Moscati,Nicole Restrepo,Peter Straub,Douglas M. Ruderfer,Victor M. Castro,Chia-Yen Chen,Chia-Yen Chen,Tian Ge,Laura M. Huckins,Alexander W. Charney,H. Lester Kirchner,Eli A. Stahl,Eli A. Stahl,Christopher F. Chabris,Lea K. Davis,Jordan W. Smoller,Jordan W. Smoller +20 more
TL;DR: The study demonstrates that an available measure of genetic risk for schizophrenia is robustly associated with schizophrenia in health care settings and has pleiotropic effects on related psychiatric disorders as well as other medical syndromes.
Journal ArticleDOI
Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome
Alden Y. Huang,Alden Y. Huang,Dongmei Yu,Dongmei Yu,Lea K. Davis,Jae Hoon Sul,Jae Hoon Sul,Fotis Tsetsos,Vasily Ramensky,Vasily Ramensky,Vasily Ramensky,Ivette Zelaya,Ivette Zelaya,Eliana Marisa Ramos,Eliana Marisa Ramos,Lisa Osiecki,Jason A. Chen,Jason A. Chen,Lauren M. McGrath,Cornelia Illmann,Paul Sandor,Cathy L. Barr,Marco A. Grados,Harvey S. Singer,Markus M. Nöthen,Johannes Hebebrand,Robert A. King,Yves Dion,Guy A. Rouleau,Cathy L. Budman,Christel Depienne,Christel Depienne,Yulia Worbe,Andreas Hartmann,Kirsten R. Müller-Vahl,Manfred Stuhrmann,Harald N. Aschauer,Mara Stamenkovic,Monika Schloegelhofer,Anastasios Konstantinidis,Gholson J. Lyon,William M. McMahon,Csaba Barta,Zsanett Tárnok,Peter Nagy,James R. Batterson,Renata Rizzo,Danielle C. Cath,Danielle C. Cath,Tomasz Wolańczyk,Cheston M. Berlin,Irene A. Malaty,Michael S. Okun,Douglas W. Woods,Douglas W. Woods,Elliott Rees,Carlos N. Pato,Michele T. Pato,James A. Knowles,Danielle Posthuma,David L. Pauls,Nancy J. Cox,Benjamin M. Neale,Benjamin M. Neale,Nelson B. Freimer,Nelson B. Freimer,Peristera Paschou,Carol A. Mathews,Jeremiah M. Scharf,Giovanni Coppola,Giovanni Coppola,Ruth D. Bruun,Sylvain Chouinard,Sabrina M. Darrow,Erica Greenberg,Matthew E. Hirschtritt,Roger Kurlan,James F. Leckman,Mary M. Robertson,Jan Smit +79 more
TL;DR: An enrichment of global CNV burden that was prominent for large (> 1 Mb), singleton events and known, pathogenic CNVs is observed, indicating that rare structural variation contributes significantly to the genetic architecture of TS.
Journal ArticleDOI
Cross-disorder genome-wide analyses suggest a complex genetic relationship between tourette's syndrome and OCD
Dongmei Yu,Carol A. Mathews,Jeremiah M. Scharf,Benjamin M. Neale,Lea K. Davis,Eric R. Gamazon,Eske M. Derks,Patrick Evans,Christopher K. Edlund,Jacquelyn Crane,Jesen Fagerness,Lisa Osiecki,Patience J. Gallagher,Gloria Gerber,Stephen A. Haddad,Cornelia Illmann,Lauren M. McGrath,Catherine Mayerfeld,Sampath Arepalli,Cristina Barlassina,Cathy L. Barr,Laura Bellodi,Fortu Benarroch,Gabriel Bedoya Berrió,O. Joseph Bienvenu,Donald W. Black,Michael H. Bloch,Helena Brentani,Ruth D. Bruun,Ruth D. Bruun,Cathy L. Budman,Cathy L. Budman,Beatriz Camarena,Desmond Campbell,Carolina Cappi,Julio C. Cardona Silgado,Maria Cristina Cavallini,Denise A. Chavira,Sylvain Chouinard,Edwin H. Cook,M.R. Cookson,Vladimir Coric,Bernadette Cullen,Daniele Cusi,Richard Delorme,D. Denys,Yves Dion,Valsama Eapen,Karin Egberts,Peter Falkai,Thomas V. Fernandez,Eduardo Fournier,Helena Garrido,Daniel A. Geller,Donald L. Gilbert,Simon Girard,Hans Joergen Grabe,Marco A. Grados,Benjamin D. Greenberg,Varda Gross-Tsur,Edna Grünblatt,John Hardy,Gary A. Heiman,Sian M. J. Hemmings,Luis Diego Herrera,Dianne M. Hezel,Pieter J. Hoekstra,Joseph Jankovic,James L. Kennedy,Robert A. King,Anuar Konkashbaev,Barbara Kremeyer,R. Kurlan,Nuria Lanzagorta,Marion Leboyer,James F. Leckman,Leonhard Lennertz,Chunyu Liu,Christine Lochner,Thomas L. Lowe,Sara Lupoli,Fabio Macciardi,Wolfgang Maier,Paolo Manunta,Maurizio Marconi,James T. McCracken,Sandra Catalina Mesa Restrepo,Rainald Moessner,Priya Moorjani,Jubel Morgan,H. Müller,Dennis L. Murphy,Allan L. Naarden,Erika L. Nurmi,William Cornejo Ochoa,Roel A. Ophoff,Roel A. Ophoff,Andrew J. Pakstis,Michele T. Pato,Carlos N. Pato,John Piacentini,Christopher Pittenger,Yehuda Pollak,Scott L. Rauch,Tobias J. Renner,Victor I. Reus,Margaret A. Richter,Mark A. Riddle,Mary M. Robertson,Roxana Romero,Maria Conceição do Rosário,David R. Rosenberg,Stephan Ruhrmann,Chiara Sabatti,Erika Salvi,Aline S. Sampaio,Aline S. Sampaio,Jack Samuels,Paul Sandor,Brooke Sheppard,Harvey S. Singer,Jan Smit,Dan J. Stein,Eric Strengman,Jay A. Tischfield,Maurizio Turiel,Ana V. Valencia Duarte,Homero Vallada,Jeremy Veenstra-VanderWeele,Susanne Walitza,Susanne Walitza,Ying Wang,Michael E. Weale,Robert B. Weiss,Jens R. Wendland,H.G.M. Westenberg,Yin Yao Shugart,Ana Gabriela Hounie,Euripedes Constantino Miguel,Humberto Nicolini,Michael Wagner,Andres Ruiz-Linares,Danielle C. Cath,Danielle C. Cath,William M. McMahon,Danielle Posthuma,Danielle Posthuma,Ben A. Oostra,Gerald Nestadt,Guy A. Rouleau,Shaun Purcell,Shaun Purcell,Shaun Purcell,Michael A. Jenike,Peter Heutink,Peter Heutink,Gregory L. Hanna,David V. Conti,Paul D. Arnold,Nelson B. Freimer,S. Evelyn Stewart,S. Evelyn Stewart,James A. Knowles,Nancy J. Cox,David L. Pauls +164 more
TL;DR: The GWAS signals were enriched for SNPs strongly associated with variations in brain gene expression levels (expression quantitative loci, or eQTLs), suggesting the presence of true functional variants that contribute to risk of these disorders.
Journal ArticleDOI
Copy number variation in obsessive-compulsive disorder and tourette syndrome : a cross-disorder study
Lauren M. McGrath,Dongmei Yu,Christian R. Marshall,Lea K. Davis,Bhooma Thiruvahindrapuram,Bingbin Li,Carolina Cappi,Gloria Gerber,Aaron B. Wolf,Frederick A. Schroeder,Lisa Osiecki,Colm O'Dushlaine,Andrew Kirby,Cornelia Illmann,Stephen A. Haddad,Patience J. Gallagher,Jesen Fagerness,Cathy L. Barr,Laura Bellodi,Fortu Benarroch,O. Joseph Bienvenu,Donald W. Black,Michael H. Bloch,Ruth D. Bruun,Cathy L. Budman,Beatriz Camarena,Danielle C. Cath,Maria Cristina Cavallini,Sylvain Chouinard,Vladimir Coric,Bernadette Cullen,Richard Delorme,Damiaan Denys,Eske M. Derks,Yves Dion,Maria Conceição do Rosário,Valsama Eapen,Patrick Evans,Peter Falkai,Thomas V. Fernandez,Helena Garrido,Daniel A. Geller,Hans J. Grabe,Marco A. Grados,Benjamin D. Greenberg,Varda Gross-Tsur,Edna Grünblatt,Gary A. Heiman,Sian M. J. Hemmings,Luis Diego Herrera,Ana Gabriela Hounie,Joseph Jankovic,James L. Kennedy,Robert A. King,Roger Kurlan,Nuria Lanzagorta,Marion Leboyer,James F. Leckman,Leonhard Lennertz,Christine Lochner,Thomas L. Lowe,Gholson J. Lyon,Fabio Macciardi,Wolfgang Maier,James T. McCracken,William M. McMahon,Dennis L. Murphy,Allan L. Naarden,Benjamin M. Neale,Erika L. Nurmi,Andrew J. Pakstis,Michele T. Pato,Carlos N. Pato,John Piacentini,Christopher Pittenger,Yehuda Pollak,Victor I. Reus,Margaret A. Richter,Mark A. Riddle,Mary M. Robertson,David R. Rosenberg,Guy A. Rouleau,Stephan Ruhrmann,Aline S. Sampaio,Jack Samuels,Paul Sandor,Brooke Sheppard,Harvey S. Singer,Jan H. Smit,Dan J. Stein,Jay A. Tischfield,Homero Vallada,Jeremy Veenstra-VanderWeele,Susanne Walitza,Susanne Walitza,Ying Wang,Jens R. Wendland,Yin Yao Shugart,Euripedes Constantino Miguel,Humberto Nicolini,Ben A. Oostra,Rainald Moessner,Michael Wagner,Andres Ruiz-Linares,Peter Heutink,Gerald Nestadt,Nelson B. Freimer,Tracey L. Petryshen,Danielle Posthuma,Michael A. Jenike,Nancy J. Cox,Gregory L. Hanna,Helena Brentani,Stephen W. Scherer,Paul D. Arnold,S. Evelyn Stewart,Carol A. Mathews,James A. Knowles,Edwin H. Cook,David L. Pauls,Kai Wang,Jeremiah M. Scharf +121 more
TL;DR: Several converging lines of evidence implicate 16p13.11 deletions in OCD, with weaker evidence for a role in TS, and the trend toward increased overall CNV burden in TS and OCD suggests that deletions previously associated with other neurodevelopmental disorders may also contribute to these phenotypes.
Journal ArticleDOI
Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE
Patrícia B. S. Celestino-Soper,Chad A. Shaw,Stephen Sanders,Jian Li,Michael T. Murtha,A. Gulhan Ercan-Sencicek,Lea K. Davis,Susanne Thomson,Tomasz Gambin,A. Craig Chinault,Zhishuo Ou,Jennifer R. German,Aleksandar Milosavljevic,James S. Sutcliffe,Edwin H. Cook,Pawel Stankiewicz,Matthew W. State,Arthur L. Beaudet +17 more
TL;DR: Data for CNVs present in lymphoblasts but absent in fresh blood DNA suggest that these represent clonal outgrowth of individual B cells with pre-existing somatic mutations rather than artifacts arising in cell culture.