L
Lea K. Davis
Researcher at Vanderbilt University Medical Center
Publications - 192
Citations - 10453
Lea K. Davis is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 34, co-authored 138 publications receiving 7193 citations. Previous affiliations of Lea K. Davis include Meharry Medical College & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
The role of sex in the genomics of human complex traits
TL;DR: Recent insights into the genetic models and mechanisms that lead to sex differences in complex traits are discussed, including genomic evidence for sex-dependent genetic architecture, models and molecular mechanisms of sexually differentiated phenotypes and implications for health care.
Journal ArticleDOI
Copy number variations on chromosome 12q14 in patients with normal tension glaucoma
John H. Fingert,Alan L. Robin,Jennifer Stone,Ben R. Roos,Lea K. Davis,Todd E. Scheetz,Steve R. Bennett,Thomas H. Wassink,Young H. Kwon,Wallace L.M. Alward,Robert F. Mullins,Val C. Sheffield,Val C. Sheffield,Edwin M. Stone +13 more
TL;DR: The data suggest that an extra copy of the encompassed TBK1 gene is likely responsible for these cases of glaucoma, and animal studies will be necessary to rule out a role for the other duplicated or neighboring genes.
Journal ArticleDOI
Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies
Dongmei Yu,Jae Hoon Sul,Fotis Tsetsos,Muhammad Nawaz,Alden Y. Huang,Ivette Zelaya,Cornelia Illmann,Lisa Osiecki,Sabrina M. Darrow,Matthew E. Hirschtritt,Erica Greenberg,Kirsten R. Müller-Vahl,Manfred Stuhrmann,Yves Dion,Guy A. Rouleau,Harald Aschauer,Mara Stamenkovic,Monika Schlögelhofer,Paul Sandor,Cathy L. Barr,Marco Grados,Harvey S Singer,Markus M. Nöthen,Johannes Hebebrand,Anke Hinney,Robert A. King,Thomas V. Fernandez,Csaba Barta,Zsanett Tarnok,Peter Nagy,Christel Depienne,Yulia Worbe,Andreas Hartmann,Cathy L. Budman,Renata Rizzo,Gholson J. Lyon,William M. McMahon,James R. Batterson,Danielle C. Cath,Irene A. Malaty,Michael S. Okun,Cheston M. Berlin,Douglas W. Woods,Paul C. Lee,Joseph Jankovic,Mary M. Robertson,Donald L Gilbert,Lawrence Brown,Barbara J Coffey,Andrea Dietrich,Pieter J. Hoekstra,Samuel Kuperman,Samuel H. Zinner,Pétur Luðvigsson,Evald Saemundsen,Ólafur Thorarensen,Gil Atzmon,Nir Barzilai,Michael Wagner,Rainald Moessner,Roel A. Ophoff,Carlos N. Pato,Michele T. Pato,James A. Knowles,Joshua L. Roffman,Jordan W. Smoller,Randy L. Buckner,A. Jeremy Willsey,Jay A. Tischfield,Gary A. Heiman,Hreinn Stefansson,K. Stefansson,Danielle Posthuma,Nancy J Cox,David L. Pauls,Nelson B. Freimer,Benjamin M. Neale,Lea K. Davis,Peristera Paschou,Giovanni Coppola,Carol A. Mathews,Jeremiah M. Scharf +81 more
TL;DR: Modulation of gene expression through noncoding variants, particularly within cortico-striatal circuits, is implicated as a fundamental mechanism in Tourette's syndrome pathogenesis, supporting the unification of Tourette’s syndrome and other tic disorders in future diagnostic schemata.
Journal ArticleDOI
Genome-wide association study of Tourette's syndrome
Jeremiah M. Scharf,Jeremiah M. Scharf,Dongmei Yu,Carol A. Mathews,Benjamin M. Neale,Benjamin M. Neale,S. E. Stewart,S. E. Stewart,Jesen Fagerness,Patrick Evans,Eric R. Gamazon,Christopher K. Edlund,Anna Tikhomirov,Lisa Osiecki,Cornelia Illmann,Anna Pluzhnikov,Anuar Konkashbaev,Lea K. Davis,Buhm Han,Jacquelyn Crane,Priya Moorjani,Priya Moorjani,Andrew Crenshaw,Melissa Parkin,Victor I. Reus,Thomas L. Lowe,Martha Rangel-Lugo,Sylvain Chouinard,Yves Dion,Simon Girard,Danielle C. Cath,Danielle C. Cath,J.H. Smit,Robert A. King,Thomas V. Fernandez,James F. Leckman,Kenneth K. Kidd,J.R. Kidd,A.J. Pakstis,Matthew W. State,Luis Diego Herrera,Roxana Romero,Eduardo Fournier,Paul Sandor,Cathy L. Barr,N. Phan,Varda Gross-Tsur,Fortu Benarroch,Yehuda Pollak,Cathy L. Budman,Cathy L. Budman,Ruth D. Bruun,Ruth D. Bruun,Gerald Erenberg,Allan L. Naarden,P. C. Lee,Nicholas T. Weiss,Barbara Kremeyer,Barbara Kremeyer,Gabriel Bedoya Berrío,Desmond Campbell,Desmond Campbell,J. C. Cardona Silgado,William Cornejo Ochoa,S. C. Mesa Restrepo,H. Müller,A. V. Valencia Duarte,A. V. Valencia Duarte,Gholson J. Lyon,Gholson J. Lyon,Mark Leppert,Jubel Morgan,Robert B. Weiss,Marco A. Grados,K. Anderson,S. Davarya,Harvey S. Singer,John T. Walkup,Joseph Jankovic,Jay A. Tischfield,Gary A. Heiman,Donald L. Gilbert,Pieter J. Hoekstra,Pieter J. Hoekstra,Mary M. Robertson,Mary M. Robertson,R. Kurlan,Chunyu Liu,J. R. Gibbs,AB Singleton,John Hardy,Eric Strengman,Eric Strengman,Roel A. Ophoff,Roel A. Ophoff,Michael Wagner,Rainald Moessner,Daniel B. Mirel,Danielle Posthuma,Danielle Posthuma,Chiara Sabatti,Eskin E,David V. Conti,James A. Knowles,Andres Ruiz-Linares,Guy A. Rouleau,Shaun Purcell,Shaun Purcell,Shaun Purcell,Peter Heutink,Ben A. Oostra,William M. McMahon,Nelson B. Freimer,Nancy J. Cox,David L. Pauls +114 more
TL;DR: This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder.
Journal ArticleDOI
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Emma C. Johnson,Ditte Demontis,Thorgeir E. Thorgeirsson,Raymond K. Walters,Renato Polimanti,Alexander S. Hatoum,Sandra Sanchez-Roige,Sarah E. Paul,Frank R. Wendt,Toni-Kim Clarke,Dongbing Lai,Gunnar W Reginsson,Hang Zhou,June He,David A.A. Baranger,Daniel F. Gudbjartsson,Robbee Wedow,Daniel E. Adkins,Amy E. Adkins,Jeffry Alexander,Silviu-Alin Bacanu,Tim B. Bigdeli,Joseph M. Boden,Sandra A. Brown,Kathleen K. Bucholz,Jonas Bybjerg-Grauholm,Robin P. Corley,Louisa Degenhardt,Danielle M. Dick,Benjamin W. Domingue,Louis Fox,Alison Goate,Scott D. Gordon,Laura M. Hack,Dana B. Hancock,Sarah M. Hartz,Ian B. Hickie,David M. Hougaard,Kenneth Krauter,Penelope A. Lind,Jeanette N. McClintick,Matthew B. McQueen,Jacquelyn L. Meyers,Grant W. Montgomery,Ole Mors,Preben Bo Mortensen,Merete Nordentoft,John F. Pearson,Roseann E. Peterson,Maureen Reynolds,John P. Rice,Valgerdur Runarsdottir,Nancy L. Saccone,Richard Sherva,Judy L. Silberg,Ralph E. Tarter,Thorarinn Tyrfingsson,Tamara L. Wall,Bradley T. Webb,Thomas Werge,Leah Wetherill,Margaret J. Wright,Stephanie Zellers,Mark Adams,Laura J. Bierut,Jason D. Boardman,William E. Copeland,Lindsay A. Farrer,Tatiana Foroud,Nathan A. Gillespie,Richard A. Grucza,Kathleen Mullan Harris,Andrew C. Heath,Victor Hesselbrock,John K. Hewitt,Christian J. Hopfer,John Horwood,William G. Iacono,Eric O. Johnson,Kenneth S. Kendler,Martin A. Kennedy,Henry R. Kranzler,Pamela A. F. Madden,Hermine H. Maes,Brion S. Maher,Nicholas G. Martin,Matt McGue,Andrew M. McIntosh,Sarah E. Medland,Elliot C. Nelson,Bernice Porjesz,Brien P. Riley,Michael C. Stallings,Michael M. Vanyukov,Scott I. Vrieze,Lea K. Davis,Ryan Bogdan,Joel Gelernter,Howard J. Edenberg,Kari Stefansson,Anders D. Børglum,Arpana Agrawal +101 more
TL;DR: These findings support the theory that Cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder.