L
Lea K. Davis
Researcher at Vanderbilt University Medical Center
Publications - 192
Citations - 10453
Lea K. Davis is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 34, co-authored 138 publications receiving 7193 citations. Previous affiliations of Lea K. Davis include Meharry Medical College & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
Synaptic processes and immune-related pathways implicated in Tourette syndrome
Fotis Tsetsos,Dongmei Yu,Dongmei Yu,Jae Hoon Sul,Jae Hoon Sul,Alden Y. Huang,Alden Y. Huang,Cornelia Illmann,Lisa Osiecki,Sabrina M Darrow,Matthew E. Hirschtritt,Erica Greenberg,Kirsten R. Müller-Vahl,Manfred Stuhrmann,Yves Dion,Guy A. Rouleau,Harald N. Aschauer,Mara Stamenkovic,Monika Schlögelhofer,Paul Sandor,Cathy L. Barr,Marco A. Grados,Harvey S. Singer,Markus M. Nöthen,Johannes Hebebrand,Anke Hinney,Robert A. King,Thomas V Fernandez,Csaba Barta,Zsanett Tarnok,Peter Nagy,Christel Depienne,Christel Depienne,Yulia Worbe,Andreas Hartmann,Cathy L. Budman,Renata Rizzo,Gholson J. Lyon,William M. McMahon,James R. Batterson,Danielle C. Cath,Irene A. Malaty,Michael S. Okun,Cheston M. Berlin,Douglas W Woods,Paul C. Lee,Joseph Jankovic,Mary M. Robertson,Donald L. Gilbert,Lawrence W. Brown,Barbara J. Coffey,Andrea Dietrich,Pieter J. Hoekstra,Samuel Kuperman,Samuel H. Zinner,Michael Wagner,James A. Knowles,A. Jeremy Willsey,Jay A Tischfield,Gary A Heiman,Nancy J. Cox,Nelson B. Freimer,Nelson B. Freimer,Benjamin M. Neale,Benjamin M. Neale,Lea K. Davis,Giovanni Coppola,Giovanni Coppola,Carol A. Mathews,Jeremiah M. Scharf,Jeremiah M. Scharf,Peristera Paschou,Sabrina M. Darrow,Roger Kurlan,James F. Leckman,Jan Smit,Gilles de la Tourette Gwas Replication Initiative,Anastasios Konstantinidis,Kirsten Müller-Vahl,Tomasz Wolańczyk,Lawrence Brown,Keun-Ah Cheon,Blanca Garcia-Delgar,Donald M. Gilbert,Dorothy E. Grice,Julie Hagstrøm,Tammy Hedderly,Tammy Hedderly,Isobel Heyman,Isobel Heyman,Chaim Huyser,Young Key Kim,Young Shin Kim,Yun-Joo Koh,Sodahm Kook,Bennett L. Leventhal,Marcos Madruga-Garrido,Pablo Mir,Astrid Morer,Alexander Münchau,Kerstin J. Plessen,Kerstin J. Plessen,Kerstin J. Plessen,Veit Roessner,Eun-Young Shin,Dong-Ho Song,Jungeun Song,Samuel H. Zinner,Thomas V. Fernandez,Gary A. Heiman,Pieter J. Hoekstra,Jay A. Tischfield,Douglas W. Woods +112 more
TL;DR: In this paper, a self-contained, set-based association method (SBA) and a competitive gene set method (MAGMA) were employed to identify three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic and cell adhesion and transsynaptic signaling processes.
Posted ContentDOI
Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits
Joanna Martin,Ekaterina A. Khramtsova,Ekaterina A. Khramtsova,Slavina B. Goleva,Gabriëlla A.M. Blokland,Gabriëlla A.M. Blokland,Michela Traglia,Raymond K. Walters,Raymond K. Walters,Christopher Hübel,Christopher Hübel,Jonathan R. I. Coleman,Gerome Breen,Anders D. Børglum,Anders D. Børglum,Ditte Demontis,Ditte Demontis,Jakob Grove,Jakob Grove,Thomas Werge,Janita Bralten,Cynthia M. Bulik,Cynthia M. Bulik,Phil Lee,Carol A. Mathews,Roseann E. Peterson,Stacey J. Winham,Naomi R. Wray,Howard J. Edenberg,Wei Guo,Yin Yao,Benjamin M. Neale,Stephen V. Faraone,Tracey L. Petryshen,Lauren A. Weiss,Laramie E. Duncan,Jill M. Goldstein,Jordan W. Smoller,Barbara E. Stranger,Barbara E. Stranger,Lea K. Davis +40 more
TL;DR: Sex differences in the common autosomal genetic architecture of neuropsychiatric and behavioral phenotypes are small and polygenic, requiring large sample sizes.
Posted ContentDOI
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
Travis T. Mallard,Richard Karlsson Linnér,Andrew D. Grotzinger,Sandra Sanchez-Roige,Jakob Seidlitz,Jakob Seidlitz,Aysu Okbay,de Vlaming R,Meddens Sfw,Abraham A. Palmer,Lea K. Davis,Elliot M. Tucker-Drob,Kenneth S. Kendler,Kenneth S. Kendler,Matthew C. Keller,Philipp Koellinger,Harden Kp +16 more
TL;DR: These findings inform psychiatric nosology and biological models of psychopathology, as they suggest the severity of mood and psychotic symptoms present in serious mental illness may reflect a difference in kind, rather than merely in degree.
Journal ArticleDOI
Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count.
Julia M. Sealock,Younga H Lee,Younga H Lee,Arden Moscati,Sanan Venkatesh,Georgios Voloudakis,Peter Straub,Kritika Singh,Yen-Chen Anne Feng,Tian Ge,Panos Roussos,Jordan W. Smoller,Jordan W. Smoller,Guanhua Chen,Lea K. Davis +14 more
TL;DR: In this article, the association between depression polygenic scores and an inflammatory biomarker, i.e., white blood cell count, was found to be bidirectional, with depression diagnosis accounting for 9.8% of the association with white blood cells.
Journal ArticleDOI
Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis.
Joe-Elie Salem,Joe-Elie Salem,M. Benjamin Shoemaker,Lisa Bastarache,Christian M. Shaffer,Andrew M. Glazer,Brett M. Kroncke,Quinn S. Wells,Mingjian Shi,Peter Straub,Gail P. Jarvik,Eric B. Larson,Eric B. Larson,Digna R. Velez Edwards,Todd L. Edwards,Lea K. Davis,Hakon Hakonarson,Chunhua Weng,David Fasel,Bjorn C. Knollmann,Thomas J. Wang,Joshua C. Denny,Patrick T. Ellinor,Patrick T. Ellinor,Dan M. Roden,Jonathan D. Mosley +25 more
TL;DR: A role for genetically determined variation in thyroid function within a physiologically accepted normal range as a risk factor for AF is suggested.