L
Lea K. Davis
Researcher at Vanderbilt University Medical Center
Publications - 192
Citations - 10453
Lea K. Davis is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 34, co-authored 138 publications receiving 7193 citations. Previous affiliations of Lea K. Davis include Meharry Medical College & Semel Institute for Neuroscience and Human Behavior.
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Posted ContentDOI
Lab-wide association scan of polygenic scores identifies biomarkers of complex disease
Jessica Dennis,Jessica Dennis,Julia M. Sealock,Peter Straub,Donald Hucks,Ky’Era Actkins,Ky’Era Actkins,Annika Faucon,Slavina B. Goleva,Maria Nirachou,Kritika Singh,Theodore Morley,Douglas M. Ruderfer,Jonathan D. Mosley,Guanhua Chen,Lea K. Davis +15 more
TL;DR: Two methods are presented, QualityLab and LabWAS, to clean and analyze EHR labs at scale in a Lab-Wide Association Scan and extend previous EHR-based analysis tools and increase the amount of EHR data usable for discovery.
Posted ContentDOI
Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization
Gita A. Pathak,Gita A. Pathak,Kritika Singh,Tyne W Miller-Fleming,Frank R. Wendt,Frank R. Wendt,Nava Ehsan,Kangcheng Hou,Ruth Johnson,Zeyun Lu,Shyamalika Gopalan,Loic Yengo,Pejman Mohammadi,Bogdan Pasaniuc,Renato Polimanti,Renato Polimanti,Lea K. Davis,Nicholas Mancuso +17 more
TL;DR: This study identified 27 genes related to inflammation and coagulation pathways whose genetically predicted expression was associated with COVID-19 hospitalization and functionally characterized the 27 genes using phenome- and laboratory-wide association scans in Vanderbilt Biobank and identified coagulations-related clinical symptoms, immunologic, and blood-cell-related biomarkers.
Posted ContentDOI
Genome-wide association study of musical beat synchronization demonstrates high polygenicity
Maria Niarchou,Daniel E. Gustavson,J. Fah Sathirapongsasuti,Manuel Anglada-Tort,Else Eising,Eamonn Bell,Eamonn Bell,Evonne McArthur,Peter Straub,J. Devin McAuley,John A. Capra,Fredrik Ullén,Fredrik Ullén,Nicole Creanza,Miriam A. Mosing,Miriam A. Mosing,Miriam A. Mosing,David A. Hinds,Lea K. Davis,Nori Jacoby,Reyna L. Gordon +20 more
TL;DR: In this paper, a genome-wide association study (GWAS) was conducted to identify common genetic variants associated with beat synchronization in 606,825 individuals, which exhibited a highly polygenic architecture, with sixty-nine loci reaching genomewide significance.
Journal ArticleDOI
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits
Gita A. Pathak,Kritika Singh,Frank R. Wendt,Tyne W. Fleming,Cassie Overstreet,Dora Koller,Daniel S. Tylee,Flavio De Angelis,B. Cabrera Mendoza,Daniel Levy,Karestan C. Koenen,John H. Krystal,Robert H. Pietrzak,Christopher O’ Donell,J. Michael Gaziano,Guido J. Falcone,Murray B. Stein,Joel Gelernter,Bogdan Pasaniuc,Nicholas Mancuso,Lea K. Davis,Renato Polimanti +21 more
TL;DR: This study finds comprehensive genomic evidence including clinical and regulatory profiles between PTSD, hematologic and cardiometabolic traits, that support comorbidities observed in epidemiologic studies of PTSD.
Posted ContentDOI
Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.
Felix R. Day,Tugce Karaderi,Matthew Jones,Cindy Meun,Chunyan He,Alexander W. Drong,Peter Kraft,Nan Lin,Hongyan Huang,Linda Broer,Reedik Mägi,Richa Saxena,Triin Laisk,Margrit Urbanek,Geoffrey Hayes,Gudmar Thorleifsson,Juan Fernández-Tajes,Anubha Mahajan,Benjamin H. Mullin,Bronwyn G. A. Stuckey,Tim D. Spector,Scott Wilson,Mark O. Goodarzi,Lea K. Davis,Barbara Obermayer-Pietsch,André G. Uitterlinden,Verneri Anttila,Benjamin M. Neale,Marjo-Riitta Järvelin,Bart C.J.M. Fauser,Irina Kowalska,Jenny A. Visser,Marianne Anderson,Ken K. Ong,Elisabet Stener-Victorin,David A. Ehrmann,Richard S. Legro,Andres Salumets,Mark I. McCarthy,Laure Morin-Papunen,Unnur Thorsteinsdottir,Kari Stefansson,Unnur Styrkarsdottir,John R. B. Perry,Andrea Dunaif,Joop S.E. Laven,Steve Franks,Cecilia M. Lindgren,Corrine K. Welt +48 more
TL;DR: A meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related traits indicates shared genetic architecture between metabolic traits and PCOS.