L
Lea K. Davis
Researcher at Vanderbilt University Medical Center
Publications - 192
Citations - 10453
Lea K. Davis is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 34, co-authored 138 publications receiving 7193 citations. Previous affiliations of Lea K. Davis include Meharry Medical College & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
The Evolutionary History of Common Genetic Variants Influencing Human Cortical Surface Area.
Amanda K. Tilot,Amanda K. Tilot,Ekaterina A. Khramtsova,Ekaterina A. Khramtsova,Dan Liang,Katrina L. Grasby,Neda Jahanshad,Jodie N. Painter,Lucía Colodro-Conde,Janita Bralten,Derrek P. Hibar,Penelope A. Lind,Siyao Liu,Sarah M Brotman,Paul M. Thompson,Sarah E. Medland,Fabio Macciardi,Barbara E. Stranger,Barbara E. Stranger,Lea K. Davis,Simon E. Fisher,Simon E. Fisher,Jason L. Stein +22 more
TL;DR: It is found that alleles with evidence of recent positive polygenic selection over the past 2000–3000 years are associated with increased surface area of the entire cortex, as well as specific regions, including those involved in spoken language and visual processing.
Journal ArticleDOI
Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
Gengjie Jia,Yu Li,Hanxin Zhang,Ishanu Chattopadhyay,Anders Boeck Jensen,David R. Blair,Lea K. Davis,Peter N. Robinson,Torsten Dahlén,Søren Brunak,Mikael Benson,Gustaf Edgren,Nancy J. Cox,Xin Gao,Andrey Rzhetsky +14 more
TL;DR: Disease prevalence curves and disease embeddings from electronic health records are computed and impute heritability for hundreds of diseases and genetic correlations for thousands of disease pairs are imputed.
Journal ArticleDOI
Elevated Polygenic Burden for Autism Spectrum Disorder Is Associated With the Broad Autism Phenotype in Mothers of Individuals With Autism Spectrum Disorder.
Kritika Nayar,Julia M. Sealock,Nell Maltman,Lauren Bush,Edwin H. Cook,Lea K. Davis,Molly Losh +6 more
TL;DR: Polygenic scores related to the broad autism phenotype are explored, highlighting the potential for a female protective factor, and implicating the polygenic etiology of ASD-related phenotypes in the BAP.
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Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.
Jessica Dennis,Julia M. Sealock,Rebecca T. Levinson,Eric Farber-Eger,Jacob Franco,Sarah Fong,Peter Straub,Donald Hucks,Wen-Liang Song,MacRae F. Linton,Pierre Fontanillas,Sarah L. Elson,Douglas M. Ruderfer,Abdel Abdellaoui,Sandra Sanchez-Roige,Abraham A. Palmer,Dorret I. Boomsma,Nancy J. Cox,Guanhua Chen,Jonathan D. Mosley,Quinn S. Wells,Lea K. Davis +21 more
TL;DR: It is concluded that genetic risk factors for MDD and loneliness act pleiotropically to increase CAD risk in females even after adjusting for multiple conventional risk factors and a polygenic score for CAD.
Journal ArticleDOI
Consensus Genotyper for Exome Sequencing (CGES): improving the quality of exome variant genotypes
Vassily Trubetskoy,Alex Rodriguez,Uptal J. Dave,Nicholas G. Campbell,Emily L. Crawford,Edwin H. Cook,James S. Sutcliffe,Ian Foster,Ravi K. Madduri,Nancy J. Cox,Lea K. Davis +10 more
TL;DR: A novel variant-calling approach based on an ensemble of variant- calling algorithms, which is term the Consensus Genotyper for Exome Sequencing (CGES), which uses a two-stage voting scheme among four algorithm implementations and yielded the fewest total variant calls.