Reiner Siebert

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: First report on molecular profiling of pediatric B-NHL showing mBL to be much more prominent in children than suggested by morphologic assessment and a molecularly homogeneous disease across children and adults.

TL;DR: The findings implicate that mnBLL,11q, is a lymphoma category distinct from BL at the molecular level, and differs from that of BL both at the chromosomal and mutational levels.

TL;DR: Signatures of eight oncogene-inducible pathways are generated which are conserved across epithelial and lymphoid tissues and identified four distinct groups of mature aggressive B-cell lymphomas across independent gene expression studies with distinct biological characteristics, genetic aberrations and prognosis.

TL;DR: In this article, the frequency and clinical relevance of mutations in ID3, TCF3 and CCND3 were analyzed within a well-defined cohort of 84 uniformly diagnosed and treated pediatric B-cell non-Hodgkin lymphoma patients of the Berlin-Frankfurt-Munster group.