M
Maria Cimpean
Researcher at Brigham and Women's Hospital
Publications - 13
Citations - 1171
Maria Cimpean is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Expression quantitative trait loci & Gene. The author has an hindex of 11, co-authored 12 publications receiving 748 citations. Previous affiliations of Maria Cimpean include Columbia University Medical Center & Broad Institute.
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Journal ArticleDOI
A transcriptomic atlas of aged human microglia
Marta Olah,Marta Olah,Ellis Patrick,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Jishu Xu,Charles C. White,Katie J. Ryan,Paul D. Piehowski,Alifiya Kapasi,Parham Nejad,Maria Cimpean,Sarah M. Connor,Sarah M. Connor,Christina J. Yung,Michael Frangieh,Allison McHenry,Wassim Elyaman,Wassim Elyaman,Vlad Petyuk,Julie A. Schneider,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw +25 more
TL;DR: The transcriptsome of aged human cortical microglia are described, and age-related gene expression as related to neurodegeneration is shown, confirming the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.
Journal ArticleDOI
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
Marta Olah,Vilas Menon,Naomi Habib,Naomi Habib,Mariko Taga,Yiyi Ma,Christina J. Yung,Maria Cimpean,Anthony Khairallah,Guillermo Coronas-Samano,Roman Sankowski,Dominic Grün,Alexandra Kroshilina,Danielle Dionne,Rani A. Sarkis,Garth Rees Cosgrove,Jeffrey Helgager,Jeffrey A. Golden,Page B. Pennell,Marco Prinz,Jean Paul Vonsattel,Andrew F. Teich,Julie A. Schneider,David A. Bennett,Aviv Regev,Wassim Elyaman,Wassim Elyaman,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw,Philip L. De Jager +29 more
TL;DR: The population structure of live microglia purified from human cerebral cortex samples obtained at autopsy and during neurosurgical procedures is investigated, and it is found that some subsets are enriched for disease-related genes and RNA signatures.
Journal ArticleDOI
CD33 modulates TREM2: convergence of Alzheimer loci
Gail Chan,Charles C. White,Phoebe A. Winn,Maria Cimpean,Joseph M. Replogle,Laura R. Glick,Nicole Cuerdon,Katie J. Ryan,Keith A. Johnson,Keith A. Johnson,Julie A. Schneider,David A. Bennett,Lori B. Chibnik,Reisa A. Sperling,Reisa A. Sperling,Elizabeth M. Bradshaw,Philip L. De Jager +16 more
TL;DR: A protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci found the NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression.
Posted ContentDOI
The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility
Nikolaos A. Patsopoulos,Sergio E. Baranzini,Adam Santaniello,Shoostari P,Chris Cotsapas,Wong G,Ashley Beecham,Tojo James,Replogle J,Ioannis S. Vlachos,Cristin McCabe,Tune H. Pers,Brandes A,Charles C. White,Brendan T. Keenan,Maria Cimpean,Winn P,Panteliadis I,Robbins A,Till F. M. Andlauer,Zarzycki O,Bénédicte Dubois,An Goris,Helle Bach Søndergaard,Finn Sellebjerg,Per Soelberg Sørensen,Henrik Ullum,Thoerner Lw,Janna Saarela,Rebeix Ic,Damotte,Bertrand Fontaine,Noel Lg,Mark Lathrop,Sandra Vukusik,Achim Berthele,Biberacher,Dorothea Buck,Christiane Gasperi,Christiane Graetz,Grummel,B. Hemmer,M.-M. Hoshi,Benjamin Knier,Thomas Korn,Christina M. Lill,Felix Luessi,Mark Mühlau,Frauke Zipp,Efthimios Dardiotis,Cristina Agliardi,Amoroso A,Nadia Barizzone,Benedetti M,Luisa Bernardinelli,Paola Cavalla,Ferdinando Clarelli,G. Comi,Daniele Cusi,Federica Esposito,Laura Ferrè,Daniela Galimberti,Clara Guaschino,Maurizio Leone,Martinelli,Moiola L,Marco Salvetti,Melissa Sorosina,Domizia Vecchio,Andrea Zauli,Silvia Santoro,Zuccalà M,Julia Y Mescheriakova,Duijn Cv,Steffan D. Bos,Elisabeth Gulowsen Celius,Anne Spurkland,Manuel Comabella,Xavier Montalban,Lars Alfredsson,Izaura Lima Bomfim,David Gomez-Cabrero,Jan Hillert,Maja Jagodic,M Lindén,Fredrik Piehl,Ilijas Jelcic,Roland Martin,Mireia Sospedra,Amie Baker,Maria Ban,Clive Hawkins,Hysi P,Seema Kalra,Fredrik Karpe,Jyoti Khadake,Genevieve Lachance,Molyneux P,Megan C Neville,J W Thorpe,Elizabeth M. Bradshaw,Stacy J. Caillier,Peter A. Calabresi,B. Cree,Anne H. Cross,Mary F. Davis,Bakker Pd,Silvia Delgado,Marieme Dembele,Keith R Edwards,Kathryn C. Fitzgerald,Frohlich I,Pierre-Antoine F. D. Gourraud,Jonathan L. Haines,Hakon Hakonarson,Dorlan J. Kimbrough,Noriko Isobe,Ioanna Konidari,Ellen Lathi,Marcus C. S. Lee,Taibo Li,An D,Zimmer A,Lo A,Lohith Madireddy,Clara P. Manrique,Mitja Mitrovic,Marta Olah,Ellis Patrick,Margaret A. Pericak-Vance,Laura Piccio,Cathy Schaefer,Howard L. Weiner,Kasper Lage,A Compston,David A. Hafler,Hanne F. Harbo,Stephen L. Hauser,Graeme J. Stewart,Sandra D'Alfonso,Giorgos M. Hadjigeorgiou,Bruce V. Taylor,Lisa F. Barcellos,David R. Booth,Rogier Q. Hintzen,Ingrid Kockum,Filippo Martinelli-Boneschi,Jacob L. McCauley,Jorge R. Oksenberg,Annette Bang Oturai,Stephen Sawcer,Ivinson A,Tommy Olsson,Phil De Jager,Murray L. Barclay,Laurent Peyrin-Biroulet,Mathias Chamaillard,Colombe J,Cottone M,Croft A,Renata D'Incà,Jonas Halfvarson,Hanigan K,Paul Henderson,Paul Henderson,Jean-Pierre Hugot,Jean-Pierre Hugot,Karban A,Nicholas A. Kennedy,Khan Ma,Marc Lémann,Arie Levine,Massey D,Monica Milla,Grant W. Montgomery,Evelyn Ng Sm,I. Oikonomou,Harald Peeters,Deborah D. Proctor,Jean-François Rahier,Roberts R,Paul Rutgeerts,Frank Seibold,Stronati L,Taylor Km,Törkvist L,Ublick K,Johan Van Limbergen,Gossum Av,Vatn Mh,Zhang H,Zhang W +191 more
TL;DR: While MS is most likely initially triggered by perturbation of peripheral immune responses the functional responses of microglia and other brain cells are also altered and may have a role in targeting an autoimmune process to the central nervous system.
Journal ArticleDOI
A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.
Katie J. Ryan,Charles C. White,Charles C. White,Kruti R. Patel,Jishu Xu,Jishu Xu,Marta Olah,Marta Olah,Joseph M. Replogle,Michael Frangieh,Michael Frangieh,Maria Cimpean,Maria Cimpean,Phoebe A. Winn,Phoebe A. Winn,Allison McHenry,Allison McHenry,Belinda J. Kaskow,Gail Chan,Nicole Cuerdon,David A. Bennett,Justin D. Boyd,Justin D. Boyd,Jaime Imitola,Wassim Elyaman,Wassim Elyaman,Philip L. De Jager,Philip L. De Jager,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw +29 more
TL;DR: In the PILRB and LRRK2 loci, the cis-eQTL was found in the MDMi cells but not in human peripheral blood monocytes, suggesting that differentiation of monocytes into microglia-like cells led to the acquisition of a cellular state that could reveal the functional consequences of certain genetic variants.