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Stephen W. Schaeffer
Researcher at Pennsylvania State University
Publications - 76
Citations - 5737
Stephen W. Schaeffer is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Drosophila pseudoobscura & Population. The author has an hindex of 32, co-authored 74 publications receiving 5365 citations. Previous affiliations of Stephen W. Schaeffer include Harvard University & National Institutes of Health.
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Journal ArticleDOI
Evolution of genes and genomes on the Drosophila phylogeny.
Andrew G. Clark,Michael B. Eisen,Michael B. Eisen,Douglas Smith,Casey M. Bergman,Brian Oliver,Therese A. Markow,Thomas C. Kaufman,Manolis Kellis,Manolis Kellis,William M. Gelbart,Venky N. Iyer,Daniel A. Pollard,Timothy B. Sackton,Amanda M. Larracuente,Nadia D. Singh,José P. Abad,Dawn N. Abt,Boris Adryan,Montserrat Aguadé,Hiroshi Akashi,Wyatt W. Anderson,Charles F. Aquadro,David H. Ardell,Roman Arguello,Carlo G. Artieri,Daniel A. Barbash,Daniel Barker,Paolo Barsanti,Phil Batterham,Serafim Batzoglou,Dave Begun,Arjun Bhutkar,Arjun Bhutkar,Enrico Blanco,Stephanie Bosak,Robert K. Bradley,Adrianne Brand,Michael R. Brent,Angela N. Brooks,Randall H. Brown,Roger K. Butlin,Corrado Caggese,Brian R. Calvi,A. Bernardo Carvalho,Anat Caspi,Sergio Castrezana,Susan E. Celniker,Jean L. Chang,Charles Chapple,Sourav Chatterji,Sourav Chatterji,Asif T. Chinwalla,Alberto Civetta,Sandra W. Clifton,Josep M. Comeron,James C. Costello,Jerry A. Coyne,Jennifer Daub,Robert David,Arthur L. Delcher,Kim D. Delehaunty,Chuong B. Do,Heather Ebling,Kevin A. Edwards,Thomas H. Eickbush,Jay D. Evans,Alan Filipski,Sven Findeiß,Sven Findeiß,Eva Freyhult,Lucinda Fulton,Robert S. Fulton,Ana Cristina Lauer Garcia,Anastasia Gardiner,David A. Garfield,Barry E. Garvin,Greg Gibson,Don Gilbert,Sante Gnerre,Jennifer Godfrey,Robert T. Good,Valer Gotea,Brenton Gravely,Anthony J. Greenberg,Sam Griffiths-Jones,Sam Griffiths-Jones,Samuel R. Gross,Roderic Guigó,Erik Gustafson,Wilfried Haerty,Matthew W. Hahn,Daniel L. Halligan,Aaron L. Halpern,Gillian M. Halter,Mira V. Han,Andreas Heger,LaDeana W. Hillier,Angie S. Hinrichs,Ian Holmes,Roger A. Hoskins,Melissa J. Hubisz,Dan Hultmark,Melanie A. Huntley,David B. Jaffe,Santosh Jagadeeshan,William R. Jeck,Justin Johnson,Corbin D. Jones,William C. Jordan,Gary H. Karpen,Gary H. Karpen,Eiko Kataoka,Peter D. Keightley,Pouya Kheradpour,Ewen F. Kirkness,Leonardo Koerich,Karsten Kristiansen,Dave Kudrna,Rob J. Kulathinal,Sudhir Kumar,Roberta Kwok,Eric S. Lander,Charles H. Langley,Richard T. Lapoint,Brian P. Lazzaro,So Jeong Lee,Lisa Levesque,Ruiqiang Li,Ruiqiang Li,Chiao-Feng Lin,Michael F. Lin,Michael F. Lin,Kerstin Lindblad-Toh,Ana Llopart,Manyuan Long,Lloyd Low,Elena R. Lozovsky,Jian Lu,Meizhong Luo,Carlos A. Machado,Wojciech Makalowski,Mar Marzo,Muneo Matsuda,Luciano M. Matzkin,Bryant F. McAllister,Carolyn S. McBride,Brendan McKernan,Kevin McKernan,Maria Mendez-Lago,Patrick Minx,Michael U. Mollenhauer,Kristi L. Montooth,Stephen M. Mount,Xu Mu,Eugene W. Myers,Bárbara Negre,Stuart J. Newfeld,Rasmus Nielsen,Mohamed A. F. Noor,Patrick M. O’Grady,Lior Pachter,Montserrat Papaceit,Matthew J. Parisi,Michael Parisi,Leopold Parts,Jakob Skou Pedersen,Jakob Skou Pedersen,Graziano Pesole,Adam M. Phillippy,Chris P. Ponting,Mihai Pop,Damiano Porcelli,Jeffrey R. Powell,Sonja J. Prohaska,Kim D. Pruitt,Marta Sabariego Puig,Hadi Quesneville,Kristipati Ravi Ram,David M. Rand,Matthew D. Rasmussen,Laura K. Reed,Robert A. Reenan,Amy Denise Reily,Karin A. Remington,Tania Tassinari Rieger,Michael G. Ritchie,Charles Robin,Yu-Hui Rogers,Claudia Rohde,Julio Rozas,Marc Rubenfield,Alfredo Ruiz,Susan M. Russo,Steven L. Salzberg,Alejandro Sánchez-Gracia,Alejandro Sánchez-Gracia,David J. Saranga,Hajime Sato,Stephen W. Schaeffer,Michael C. Schatz,Todd A. Schlenke,Russell Schwartz,Carmen Segarra,Rama S. Singh,Laura K. Sirot,Marina Sirota,Nicholas Sisneros,Christopher D. Smith,Christopher D. Smith,Temple F. Smith,John Spieth,Deborah E. Stage,Alexander Stark,Alexander Stark,Wolfgang Stephan,Robert L. Strausberg,Sebastian Strempel,David Sturgill,Granger G. Sutton,Granger G. Sutton,Wei Tao,Sarah A. Teichmann,Yoshiko N. Tobari,Yoshihiko Tomimura,Jason M. Tsolas,Vera L. S. Valente,Eli Venter,J. Craig Venter,Saverio Vicario,Filipe G. Vieira,Albert J. Vilella,Alfredo Villasante,Brian P. Walenz,Jun Wang,Jun Wang,Marvin Wasserman,Thomas D. Watts,Derek Wilson,Richard K. Wilson,Rod A. Wing,Mariana F. Wolfner,Alex Wong,Gane Ka-Shu Wong,Gane Ka-Shu Wong,Chung-I Wu,Gabriel C. Wu,Daisuke Yamamoto,Hsiao Pei Yang,Shiaw Pyng Yang,James A. Yorke,Kiyohito Yoshida,Evgeny M. Zdobnov,Peili Zhang,Yu Zhang,Aleksey V. Zimin,Jennifer Baldwin,Amr Abdouelleil,Jamal Abdulkadir,Adal Abebe,Brikti Abera,Justin Abreu,St Christophe Acer,Lynne Aftuck,Allen Alexander,Peter An,Erica Anderson,Scott Anderson,Harindra Arachi,Marc Azer,Pasang Bachantsang,Andrew Barry,Tashi Bayul,Aaron M. Berlin,Daniel Bessette,Toby Bloom,Jason Blye,Leonid Boguslavskiy,Claude Bonnet,Boris Boukhgalter,Imane Bourzgui,Adam Brown,Patrick Cahill,Sheridon Channer,Yama Cheshatsang,Lisa Chuda,Mieke Citroen,Alville Collymore,Patrick Cooke,Maura Costello,Katie D'Aco,Riza M. Daza,Georgius De Haan,Stuart DeGray,Christina Demaso,Norbu Dhargay,Kimberly Dooley,Erin E. Dooley,Missole Doricent,Passang Dorje,Kunsang Dorjee,Alan Dupes,Richard Elong,Jill Falk,Abderrahim Farina,Susan Faro,Diallo Ferguson,Sheila Fisher,Chelsea D. Foley,Alicia Franke,Dennis C. Friedrich,Loryn Gadbois,Gary Gearin,Christina R. Gearin,Georgia Giannoukos,Tina Goode,Joseph Graham,Edward Grandbois,Sharleen Grewal,Kunsang Gyaltsen,Nabil Hafez,Birhane Hagos,Jennifer L. Hall,Charlotte Henson,Andrew Hollinger,Tracey Honan,Monika D. Huard,Leanne Hughes,Brian Hurhula,M. Erii Husby,Asha Kamat,Ben Kanga,Seva Kashin,Dmitry Khazanovich,Peter Kisner,Krista Lance,Marcia Lara,William Lee,Niall J. Lennon,Frances Letendre,Rosie Levine,Alex Lipovsky,Xiaohong Liu,Jinlei Liu,Shangtao Liu,Tashi Lokyitsang,Yeshi Lokyitsang,Rakela Lubonja,Annie Lui,Pen MacDonald,Vasilia Magnisalis,Kebede Maru,Charles Matthews,William McCusker,Susan McDonough,Teena Mehta,James Meldrim,Louis Meneus,Oana Mihai,Atanas Mihalev,Tanya Mihova,Rachel Mittelman,Valentine Mlenga,Anna Montmayeur,Leonidas Mulrain,Adam Navidi,Jerome Naylor,Tamrat Negash,Thu Nguyen,Nga Nguyen,Robert Nicol,Choe Norbu,Nyima Norbu,Nathaniel Novod,Barry O'Neill,Sahal Osman,Eva Markiewicz,Otero L. Oyono,Christopher Patti,Pema Phunkhang,Fritz Pierre,Margaret Priest,Sujaa Raghuraman,Filip Rege,Rebecca Reyes,Cecil Rise,Peter Rogov,Keenan Ross,Elizabeth P. Ryan,Sampath Settipalli,Terry Shea,Ngawang Sherpa,Lu Shi,Diana Shih,Todd Sparrow,Jessica Spaulding,John Stalker,Nicole Stange-Thomann,Sharon Stavropoulos,Catherine Stone,Christopher Strader,Senait Tesfaye,Talene Thomson,Yama Thoulutsang,Dawa Thoulutsang,Kerri Topham,Ira Topping,Tsamla Tsamla,Helen Vassiliev,Andy Vo,Tsering Wangchuk,Tsering Wangdi,Michael Weiand,Jane Wilkinson,Adam Wilson,Shailendra Yadav,Geneva Young,Qing Yu,Lisa Zembek,Danni Zhong,Andrew Zimmer,Zac Zwirko,Pablo Alvarez,William Brockman,Jonathan Butler,Cheewhye Chin,Manfred Grabherr,Michael Kleber,Evan Mauceli,Iain MacCallum +429 more
TL;DR: These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution.
Journal ArticleDOI
Comparative genome sequencing of Drosophila pseudoobscura: Chromosomal, gene, and cis-element evolution
Stephen Richards,Yue Liu,Bettencourt Brian,Pavel Hradecky,Stan Letovsky,Rasmus Nielsen,Kevin R. Thornton,Melissa J. Hubisz,Rui Chen,Richard P. Meisel,Olivier Couronne,Olivier Couronne,Sujun Hua,Mark A. Smith,Peili Zhang,Jing Liu,Harmen J. Bussemaker,Marinus F. van Batenburg,Marinus F. van Batenburg,Sally Howells,Steven E. Scherer,Erica Sodergren,Beverly B. Matthews,Madeline A. Crosby,Andrew J. Schroeder,Daniel Ortiz-Barrientos,Catharine M. Rives,Michael L. Metzker,Donna M. Muzny,Graham R. Scott,David Steffen,David A. Wheeler,Kim C. Worley,Paul Havlak,K. James Durbin,Amy Egan,Rachel Gill,Jennifer Hume,Margaret Morgan,George Miner,Cerissa Hamilton,Yanmei Huang,Lenee Waldron,Daniel Verduzco,Kerstin P. Clerc-Blankenburg,Inna Dubchak,Mohamed A. F. Noor,Wyatt W. Anderson,Kevin P. White,Andrew G. Clark,Stephen W. Schaeffer,William M. Gelbart,George M. Weinstock,Richard A. Gibbs +53 more
TL;DR: A pattern of repeat-mediated chromosomal rearrangement, and high coadaptation of both male genes and cis-regulatory sequences emerges as important themes of genome divergence between these species of Drosophila.
Journal ArticleDOI
Polytene Chromosomal Maps of 11 Drosophila Species: The Order of Genomic Scaffolds Inferred From Genetic and Physical Maps
Stephen W. Schaeffer,Arjun Bhutkar,Arjun Bhutkar,Bryant F. McAllister,Muneo Matsuda,Luciano M. Matzkin,Patrick M. O’Grady,Claudia Rohde,Vera L. S. Valente,Montserrat Aguadé,Wyatt W. Anderson,Kevin A. Edwards,Ana Cristina Lauer Garcia,Josh Goodman,James Hartigan,Eiko Kataoka,Richard T. Lapoint,Elena R. Lozovsky,Carlos A. Machado,Mohamed A. F. Noor,Montserrat Papaceit,Laura K. Reed,Stephen Richards,Tania Tassinari Rieger,Susan M. Russo,Hajime Sato,Carmen Segarra,Douglas Smith,Temple F. Smith,Victor B. Strelets,Yoshiko N. Tobari,Yoshihiko Tomimura,Marvin Wasserman,Thomas D. Watts,Robert L. Wilson,Kiyohito Yoshida,Therese A. Markow,William M. Gelbart,William M. Gelbart,Thomas C. Kaufman +39 more
TL;DR: The sequencing of the 12 genomes of members of the genus Drosophila was taken as an opportunity to reevaluate the genetic and physical maps for 11 of the species, in part to aid in the mapping of assembled scaffolds.
Journal ArticleDOI
Chromosomal Rearrangement Inferred From Comparisons of 12 Drosophila Genomes
TL;DR: The results provide estimated chromosomal evolution rates across this set of species on the basis of whole-genome synteny analysis, which are found to be higher than those previously reported.
Journal ArticleDOI
Natural Selection and the Frequency Distributions of “Silent” DNA Polymorphism in Drosophila
TL;DR: The existence of fitness classes of silent mutations is confirmed and maximum likelihood estimates suggest that selection intensity at silent sites is, on average, very weak in both D. pseudoobscura and D. simulans.