M
Mark Walker
Researcher at University of Ottawa
Publications - 690
Citations - 63950
Mark Walker is an academic researcher from University of Ottawa. The author has contributed to research in topics: Population & Pregnancy. The author has an hindex of 97, co-authored 622 publications receiving 58554 citations. Previous affiliations of Mark Walker include Newcastle University & Queen's University.
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Journal ArticleDOI
DNA damage induces Chk1‐dependent centrosome amplification
Emer Bourke,Helen Dodson,Andreas Merdes,Lorraine Cuffe,George Zachos,Mark Walker,David A. F. Gillespie,Ciaran G. Morrison +7 more
TL;DR: Caffeine abrogated centrosome amplification in both ATM (ataxia telangiectasia, mutated)‐ and ATR (ATM and Rad3‐related)‐defective cells, indicating a complementary role for these DNA‐damage‐responsive kinases in promoting centrosomes amplification.
Journal ArticleDOI
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Anders Albrechtsen,Niels Grarup,Yun Li,Thomas Sparsø,G. Tian,H. Cao,T. Jiang,S. Y. Kim,Thorfinn Sand Korneliussen,Q. Li,Chao Nie,R. Wu,Line Skotte,Andrew P. Morris,Claes Ladenvall,Stéphane Cauchi,Alena Stančáková,Gregers S. Andersen,Arne Astrup,Karina Banasik,Amanda J. Bennett,Lars Bolund,Guillaume Charpentier,Yi Chen,J. M. Dekker,Alex S. F. Doney,Mozhgan Dorkhan,Tom Forsén,Timothy M. Frayling,Christopher J. Groves,Y. Gui,Göran Hallmans,Andrew T. Hattersley,Kunlun He,Graham A. Hitman,Johan Holmkvist,S. Huang,H. Jiang,Xin Jin,Johanne Marie Justesen,Karsten Kristiansen,Johanna Kuusisto,Maria Lajer,Olivier Lantieri,Weijing Li,H. Liang,Q. Liao,X. Liu,T. Ma,X. Ma,M. P. Manijak,Michel Marre,Michel Marre,Jacek Mokrosinski,Andrew D. Morris,B. Mu,Aneta Aleksandra Nielsen,Giel Nijpels,Peter M. Nilsson,Colin N. A. Palmer,Nigel W. Rayner,Nigel W. Rayner,Frida Renström,Rasmus Ribel-Madsen,Neil Robertson,Neil Robertson,Olov Rolandsson,Peter Rossing,Thue W. Schwartz,P.E. Slagboom,Maria Sterner,M. Tang,Lise Tarnow,Tiinamaija Tuomi,E. van 't Riet,N. van Leeuwen,Tibor V. Varga,Marie A. Vestmar,Mark Walker,B. Wang,Y. Wang,H. Wu,F. Xi,Loic Yengo,Chang Yu,Xiaoming Zhang,J. Zhang,Q. Zhang,Weihua Zhang,H. Zheng,Y. Zhou,David Altshuler,David Altshuler,Leen M 't Hart,Paul W. Franks,Paul W. Franks,Paul W. Franks,B. Balkau,Philippe Froguel,Philippe Froguel,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Markku Laakso,Leif Groop,Cramer Christensen,Ivan Brandslund,Torsten Lauritzen,Daniel R. Witte,Allan Linneberg,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Torben Hansen,Jun Wang,Rasmus Nielsen,Rasmus Nielsen,Oluf Pedersen +118 more
TL;DR: Exome sequencing is applied as a basis for finding genetic determinants of metabolic traits and show the existence of low-frequency and common coding polymorphisms with impact on common metabolic traits.
Journal ArticleDOI
A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction.
TL;DR: This meta-analysis of case-control studies suggests that the factor V Leiden and prothrombin gene variant both confer an increased risk of giving birth to an intrauterine growth restricted infant, although this may be driven by small, poor-quality studies that demonstrated extreme associations.
Journal ArticleDOI
H1N1 Influenza Vaccination During Pregnancy and Fetal and Neonatal Outcomes
Deshayne B. Fell,Ann E. Sprague,Ning Liu,Abdool S. Yasseen,Shi Wu Wen,Graeme N. Smith,Mark Walker +6 more
TL;DR: It is suggested that second- or third-trimester H1N1 vaccination was associated with improved fetal and neonatal outcomes during the recent pandemic.
A Central Role for GRB10 in Regulation of Islet Function in Man
Inga Prokopenko,Wenny Poon,Reedik Maegi,Rashmi B. Prasad,S Albert Salehi,Peter Almgren,Peter Osmark,Nabila Bouatia-Naji,Nils Wierup,Tove Fall,Alena Stančáková,Adam Barker,Vasiliki Lagou,Clive Osmond,Weijia Xie,Jari Lahti,Anne U. Jackson,Yu-Ching Cheng,Jie Liu,Jeffrey R. O'Connell,Paul Blomstedt,João Fadista,Sami Alkayyali,Tasnim Dayeh,Emma Ahlqvist,Jalal Taneera,Cécile Lecoeur,Ashok Kumar,Ola Hansson,Karin M Hansson,Benjamin F. Voight,Hyun Min Kang,Claire Levy-Marchal,Vincent Vatin,Aarno Palotie,Ann-Christine Syvänen,Andrea Mari,Michael N. Weedon,Ruth J. F. Loos,Ken K. Ong,Peter M. Nilsson,Bo Isomaa,Tiinamaija Tuomi,Nicholas J. Wareham,Michael Stumvoll,Elisabeth Widen,Timo A. Lakka,Claudia Langenberg,Anke Tönjes,Rainer Rauramaa,Johanna Kuusisto,Timothy M. Frayling,Philippe Froguel,Mark Walker,Johan G. Eriksson,Charlotte Ling,Peter Kovacs,Erik Ingelsson,Mark I. McCarthy,Alan R. Shuldiner,Kristi D. Silver,Markku Laakso,Leif Groop,Valeriya Lyssenko +63 more
TL;DR: Findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis.