M
Mark Walker
Researcher at University of Ottawa
Publications - 690
Citations - 63950
Mark Walker is an academic researcher from University of Ottawa. The author has contributed to research in topics: Population & Pregnancy. The author has an hindex of 97, co-authored 622 publications receiving 58554 citations. Previous affiliations of Mark Walker include Newcastle University & Queen's University.
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Rare and low-frequency coding variants alter human adult height
Eirini Marouli,Mariaelisa Graff,Carolina Medina-Gomez,Ken Sin Lo,Andrew R. Wood,Troels R. Kjaer,Rebecca S. Fine,Yingchang Lu,Claudia Schurmann,Heather M. Highland,Sina Rüeger,Gudmar Thorleifsson,Anne E. Justice,David Lamparter,Kathleen Stirrups,Valérie Turcot,Kristin L. Young,Thomas W. Winkler,Tõnu Esko,Tugce Karaderi,Adam E. Locke,Nicholas G. D. Masca,Maggie C.Y. Ng,Poorva Mudgal,Manuel A. Rivas,Sailaja Vedantam,Anubha Mahajan,Xiuqing Guo,Gonçalo R. Abecasis,Katja K.H. Aben,Linda S. Adair,Dewan S. Alam,Eva Albrecht,Kristine H. Allin,Matthew A. Allison,Philippe Amouyel,Emil V. R. Appel,Dominique Arveiler,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Bernhard Banas,Lia E. Bang,Marianne Benn,Sven Bergmann,Lawrence F. Bielak,Matthias Blueher,Heiner Boeing,Eric Boerwinkle,Carsten A. Boeger,Lori L. Bonnycastle,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Murray H. Brilliant,Linda Broer,Amber A. Burt,Adam S. Butterworth,David J. Carey,Mark J. Caulfield,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Gabriel Cuellar-Partida,John Danesh,Gail Davies,Paul I.W. de Bakker,Gert J. de Borst,Simon de Denus,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Anneke I. den Hollander,Joe Dennis,Emanuele Di Angelantonio,Fotios Drenos,Mengmeng Du,Alison M. Dunning,Douglas F. Easton,Tapani Ebeling,Todd L. Edwards,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Jessica D. Faul,Mary F. Feitosa,Shuang Feng,Ele Ferrannini,Marco M Ferrario,Jean Ferrières,Jose C. Florez,Ian Ford,Myriam Fornage,Paul W. Franks,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Ayush Giri,Giorgia Girotto,Scott D. Gordon,Penny Gordon-Larsen,Mathias Gorski,Niels Grarup,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Caroline Hayward,Liang He,Iris M. Heid,Kauko Heikkilä,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Lynne J. Hocking,Mette Hollensted,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Carel B. Hoyng,Paul L. Huang,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Min A. Jhun,Yucheng Jia,Xuejuan Jiang,Stefan Johansson,Marit E. Jørgensen,Torben Jørgensen,Pekka Jousilahti,J. Wouter Jukema,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Renske Keeman,Lambertus A. Kiemeney,Hidetoshi Kitajima,Kirsten B. Kluivers,Thomas D. Kocher,Pirjo Komulainen,Jukka Kontto,Jaspal S. Kooner,Charles Kooperberg,Peter Kovacs,Jennifer Kriebel,Helena Kuivaniemi,Sébastien Küry,Johanna Kuusisto,Martina La Bianca,Markku Laakso,Timo A. Lakka,Ethan M. Lange,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Eric B. Larson,I-Te Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Y Liu,Yongmei Liu,Artitaya Lophatananon,Jian'an Luan,Steven A. Lubitz,Leo-Pekka Lyytikäinen,David A. Mackey,Pamela A. F. Madden,Alisa K. Manning,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas G. Martin,Angela L. Mazul,Karina Meidtner,Andres Metspalu,Paul Mitchell,Karen L. Mohlke,Dennis O. Mook-Kanamori,Anna Morgan,Andrew D. Morris,Andrew P. Morris,Martina Mueller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Matthias Nauck,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Ioanna Ntalla,Jeffrey R. O'Connel,Heikki Oksa,Loes M. Olde Loohuis,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,James A. Perry,John R. B. Perry,Thomas N. Person,Ailith Pirie,Ozren Polasek,Danielle Posthuma,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Alexander P. Reiner,Frida Renström,Paul M. Ridker,John D. Rioux,Neil Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Kevin Sandow,Yadav Sapkota,Naveed Sattar,Marjanka K. Schmidt,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Albert V. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael Stumvoll,Praveen Surendran,Leen M 't Hart,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Toenjes,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Sheila Ulivi,Sander W. van der Laan,Andries R. van der Leij,Cornelia M. van Duijn,Natasja M. van Schoor,Jessica van Setten,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Diego Vozzi,Mark Walker,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Nicholas J. Wareham,Helen R. Warren,Jennifer Wessel,Sara M. Willems,James G. Wilson,Daniel R. Witte,Michael O. Woods,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,Jerome I. Rotter,Michael Boehnke,Sekar Kathiresan,Mark I. McCarthy,Cristen J. Willer,Kari Stefansson,Ingrid B. Borecki,Dajiang J. Liu,Kari E. North,Nancy L. Heard-Costa,Tune H. Pers,Cecilia M. Lindgren,Claus Oxvig,Zoltán Kutalik,Fernando Rivadeneira,Ruth J. F. Loos,Timothy M. Frayling,Joel N. Hirschhorn,Panos Deloukas,Guillaume Lettre +370 more
TL;DR: The results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
Journal ArticleDOI
Common variants in WFS1 confer risk of type 2 diabetes
Manjinder S. Sandhu,Manjinder S. Sandhu,Michael N. Weedon,Katherine A. Fawcett,Jon Wasson,Sally L Debenham,Allan Daly,Hana Lango,Timothy M. Frayling,Rosalind J Neumann,Richard Sherva,Ilana Blech,Paul D.P. Pharoah,Paul D.P. Pharoah,Colin N. A. Palmer,Charlotte H. Kimber,Roger Tavendale,Andrew D. Morris,Mark I. McCarthy,Mark I. McCarthy,Mark Walker,Graham A. Hitman,Benjamin Glaser,M. Alan Permutt,Andrew T. Hattersley,Nicholas J. Wareham,Inês Barroso +26 more
TL;DR: Using a gene-centric approach, it is shown that variation in WFS1 also predisposes to common type 2 diabetes.
Journal ArticleDOI
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Rona J. Strawbridge,Josée Dupuis,Inga Prokopenko,Adam Barker,Emma Ahlqvist,Denis Rybin,John R. Petrie,Mary E. Travers,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Antigone S. Dimas,Antigone S. Dimas,Alexandra C. Nica,Alexandra C. Nica,Eleanor Wheeler,Han Chen,Benjamin F. Voight,Benjamin F. Voight,Jalal Taneera,Stavroula Kanoni,Stavroula Kanoni,J F Peden,Fabiola Turrini,Fabiola Turrini,Stefan Gustafsson,Carina Zabena,Peter Almgren,Barker Djp,Daniel R. Barnes,Elaine M. Dennison,Johan G. Eriksson,Per Eriksson,Elodie Eury,Elodie Eury,Lasse Folkersen,Caroline S. Fox,Caroline S. Fox,Timothy M. Frayling,Anuj Goel,Harvest F. Gu,Momoko Horikoshi,Bo Isomaa,Anne U. Jackson,Karen A. Jameson,Eero Kajantie,Julie Kerr-Conte,Julie Kerr-Conte,Teemu Kuulasmaa,Johanna Kuusisto,Loos Rjf.,Jian'an Luan,Konstantinos Makrilakis,Alisa K. Manning,María Teresa Martínez-Larrad,Narisu Narisu,M Nastase Mannila,John Öhrvik,Clive Osmond,Laura Pascoe,Felicity Payne,Avan Aihie Sayer,Bengt Sennblad,Angela Silveira,Alena Stančáková,K Stirrups,Amy J. Swift,Syvänen A-C.,Tiinamaija Tuomi,F.M. van 't Hooft,Mark Walker,Michael N. Weedon,Weijia Xie,Björn Zethelius,Halit Ongen,Anders Mälarstig,Jemma C. Hopewell,Danish Saleheen,J Chambers,Sarah Parish,John Danesh,J Kooner,Ostenson C-G.,Lars Lind,Cyrus Cooper,Manuel Serrano-Ríos,Ele Ferrannini,Tom Forsén,Robert Clarke,MariaGrazia Franzosi,Udo Seedorf,Hugh Watkins,Philippe Froguel,Paul Johnson,Panos Deloukas,Panos Deloukas,Francis S. Collins,Markku Laakso,Emmanouil T. Dermitzakis,Michael Boehnke,Mark I. McCarthy,Nicholas J. Wareham,Leif Groop,François Pattou,François Pattou,Anna L. Gloyn,George Dedoussis,Valeriya Lyssenko,James B. Meigs,Inês Barroso,Inês Barroso,Inês Barroso,Richard M. Watanabe,Erik Ingelsson,Claudia Langenberg,Anders Hamsten,Jose C. Florez,Jose C. Florez +116 more
TL;DR: The findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis.
Journal ArticleDOI
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Marcel den Hoed,Mark Eijgelsheim,Tõnu Esko,Bianca J. J. M. Brundel,David S. Peal,David M. Evans,Ilja M. Nolte,Ayellet V. Segrè,Hilma Holm,Robert E. Handsaker,Harm-Jan Westra,Toby Johnson,Aaron Isaacs,Jian Yang,Alicia Lundby,Jing Hua Zhao,Young Jin Kim,Min Jin Go,Peter Almgren,Murielle Bochud,Gabrielle Boucher,Marilyn C. Cornalis,Daniel F. Gudbjartsson,David Hadley,Pim van der Harst,Caroline Hayward,Martin den Heijer,Wilmar Igl,Anne U. Jackson,Zoltán Kutalik,Jian'an Luan,John P. Kemp,Kati Kristiansson,Claes Ladenvall,Mattias Lorentzon,May E. Montasser,Omer T. Njajou,Paul F. O'Reilly,Sandosh Padmanabhan,Beate St Pourcain,Tuomo Rankinen,Perttu Salo,Toshiko Tanaka,Nicholas J. Timpson,Veronique Vitart,Lindsay L. Waite,William Wheeler,Weihua Zhang,Harmen H.M. Draisma,Mary F. Feitosa,Kathleen F. Kerr,Penelope A. Lind,Evelin Mihailov,N. Charlotte Onland-Moret,Ci Song,Michael N. Weedon,Weijia Xie,Loic Yengo,Devin Absher,Christine M. Albert,Alvaro Alonso,Dan E. Arking,Paul I.W. de Bakker,Beverley Balkau,Cristina Barlassina,Paola Benaglio,Joshua C. Bis,Nabila Bouatia-Naji,Soren Brage,Stephen J. Chanock,Peter S. Chines,Mina K. Chung,Dawood Darbar,Christian Dina,Marcus Dörr,Paul Elliott,Stephan B. Felix,Krista Fischer,Christian Fuchsberger,Eco J. C. de Geus,Philippe Goyette,Vilmundur Gudnason,Tamara B. Harris,Anna-Liisa Hartikainen,Aki S. Havulinna,Susan R. Heckbert,Andrew A. Hicks,Albert Hofman,Suzanne Holewijn,Femke Hoogstra-Berends,Jouke-Jan Hottenga,Majken K. Jensen,Åsa Johansson,Juhani Junttila,Stefan Kääb,Bart Kanon,Shamika Ketkar,Kay-Tee Khaw,Joshua W. Knowles,Angad S. Kooner,Jan A. Kors,Meena Kumari,Lili Milani,Päivi Laiho,Edward G. Lakatta,Claudia Langenberg,Maarten Leusink,Yongmei Liu,Robert Luben,Kathryn L. Lunetta,Stacey N. Lynch,Marcello Ricardo Paulista Markus,Pedro Marques-Vidal,Irene Mateo Leach,Wendy L. McArdle,Steven A. McCarroll,Sarah E. Medland,Kathryn Miller,Grant W. Montgomery,Alanna C. Morrison,Martina Müller-Nurasyid,Pau Navarro,Mari Nelis,Jeffrey R. O'Connell,Christopher J. O'Donnell,Ken K. Ong,Anne B. Newman,Annette Peters,Ozren Polasek,Anneli Pouta,Peter P. Pramstaller,Bruce M. Psaty,Dabeeru C. Rao,Susan M. Ring,Elizabeth J. Rossin,Diana Rudan,Serena Sanna,Robert A. Scott,Jaban S. Sehmi,Stephen J. Sharp,Jordan T. Shin,Andrew B. Singleton,Albert V. Smith,Nicole Soranzo,Tim D. Spector,Chip Stewart,Heather M. Stringham,Kirill V. Tarasov,André G. Uitterlinden,Liesbeth Vandenput,Shih-Jen Hwang,John Whitfield,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Jacqueline C. M. Witteman,Andrew Wong,Quenna Wong,Yalda Jamshidi,Paavo Zitting,Jolanda M. A. Boer,Dorret I. Boomsma,Ingrid B. Borecki,Cornelia M. van Duijn,Ulf Ekelund,Nita G. Forouhi,Philippe Froguel,Aroon D. Hingorani,Erik Ingelsson,Mika Kivimäki,Richard A. Kronmal,Diana Kuh,Lars Lind,Nicholas G. Martin,Ben A. Oostra,Nancy L. Pedersen,Thomas Quertermous,Jerome I. Rotter,Yvonne T. van der Schouw,W. M. Monique Verschuren,Mark Walker,Demetrius Albanes,David O. Arnar,Themistocles L. Assimes,Stefania Bandinelli,Michael Boehnke,Rudolf A. de Boer,Claude Bouchard,L Mark Caulfield W L Mark Caulfield,John C. Chambers,Gary C. Curhan,Daniele Cusi,Johan G. Eriksson,Luigi Ferrucci,Wiek H. van Gilst,Nicola Glorioso,Jacqueline de Graaf,Leif Groop,Ulf Gyllensten,Wen Chi Hsueh,Frank B. Hu,Heikki V. Huikuri,David J. Hunter,Carlos Iribarren,Bo Isomaa,Marjo-Riitta Järvelin,Antti Jula,Mika Kähönen,Lambertus A. Kiemeney,Melanie M. van der Klauw,Jaspal S. Kooner,Peter Kraft,Licia Iacoviello,Terho Lehtimäki,Marja-Liisa Lokki,Braxton D. Mitchell,Gerjan Navis,Markku S. Nieminen,Claes Ohlsson,Neil Poulter,Lu Qi,Olli T. Raitakari,Eric B. Rimm,John D. Rioux,Federica Rizzi,Igor Rudan,Veikko Salomaa,Peter S. Sever,Denis C. Shields,Alan R. Shuldiner,Juha Sinisalo,Alice Stanton,Ronald P. Stolk,David P. Strachan,Jean-Claude Tardif,Unnur Thorsteinsdottir,J. Tuomilehto,Dirk J. van Veldhuisen,Jarmo Virtamo,Jorma Viikari,Peter Vollenweider,Gérard Waeber,Elisabeth Widen,Yoon Shin Cho,Jesper V. Olsen,Peter M. Visscher,Cristen J. Willer,Lude Franke,Jeanette Erdmann,John R. Thompson,Arne Pfeufer,Nona Sotoodehnia,Christopher Newton-Cheh,Patrick T. Ellinor,Bruno H. Stricker,Andres Metspalu,Markus Perola,Jacques S. Beckmann,George Davey Smith,Kari Stefansson,Nicholas J. Wareham,Patricia B. Munroe,Ody C. M. Sibon,David J. Milan,Harold Snieder,Nilesh J. Samani,Ruth J. F. Loos +267 more
TL;DR: A 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci, providing fresh insights into the mechanisms regulating heart rate.
Journal ArticleDOI
A Genomewide Scan for Loci Predisposing to Type 2 Diabetes in a U.K. Population (The Diabetes UK Warren 2 Repository): Analysis of 573 Pedigrees Provides Independent Replication of a Susceptibility Locus on Chromosome 1q
Steven Wiltshire,Steven Wiltshire,Andrew T. Hattersley,Graham A. Hitman,Mark Walker,Jonathan C. Levy,Mike Sampson,Stephen O'Rahilly,Timothy M. Frayling,John I. Bell,John I. Bell,G. Mark Lathrop,Amanda J. Bennett,Amanda J. Bennett,Ranjit Dhillon,Christopher Fletcher,C J Groves,Elizabeth C. Jones,Philip Prestwich,Nikol Simecek,Pamidighantam V. Subba Rao,Marie Wishart,Richard Foxon,Simon L. Howell,Damian Smedley,Lon R. Cardon,Stephan Menzel,Mark I. McCarthy +27 more
TL;DR: These data, derived from one of the largest genome scans undertaken in this condition, confirm that individual susceptibility-gene effects for type 2 diabetes are likely to be modest in size and should accelerate positional cloning efforts in these regions of interest.