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Matthew Kroll
Researcher at Allen Institute for Brain Science
Publications - 22
Citations - 4001
Matthew Kroll is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Neocortex & Cell type. The author has an hindex of 14, co-authored 22 publications receiving 1782 citations.
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Journal ArticleDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Lucas T. Graybuck,Kimberly A. Smith,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Sheana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Heather A. Sullivan,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +48 more
TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
Posted ContentDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Kimberly A. Smith,Lucas T. Graybuck,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Seana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +46 more
TL;DR: A combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct regions of the mouse cortex is established and correspondence between excitatory transcriptomic types and their region-specific long-range target specificity is demonstrated.
Journal ArticleDOI
Single-nucleus and single-cell transcriptomes compared in matched cortical cell types.
Trygve E. Bakken,Rebecca D. Hodge,Jeremy A. Miller,Zizhen Yao,Thuc Nghi Nguyen,Brian D. Aevermann,Eliza Barkan,Darren Bertagnolli,Tamara Casper,Nick Dee,Emma Garren,Jeff Goldy,Lucas T. Graybuck,Matthew Kroll,Roger S. Lasken,Kanan Lathia,Sheana Parry,Christine Rimorin,Richard H. Scheuermann,Nicholas J. Schork,Soraya I. Shehata,Michael Tieu,John W. Phillips,Amy Bernard,Kimberly A. Smith,Hongkui Zeng,Ed Lein,Bosiljka Tasic +27 more
TL;DR: It is demonstrated that closely related neuronal cell types can be similarly discriminated with both methods if intronic sequences are included in snRNA-seq analysis, and the high information content of nuclear RNA for characterization of cellular diversity in brain tissues is illustrated.
Journal ArticleDOI
Classification of electrophysiological and morphological neuron types in the mouse visual cortex.
Nathan W. Gouwens,Staci A. Sorensen,Jim Berg,Changkyu Lee,Tim Jarsky,Jonathan T. Ting,Susan M. Sunkin,David Feng,Costas A. Anastassiou,Eliza Barkan,Kris Bickley,Nicole Blesie,Thomas Braun,Krissy Brouner,Agata Budzillo,Shiella Caldejon,Tamara Casper,Dan Castelli,Peter Chong,Kirsten Crichton,Christine Cuhaciyan,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Tsega Desta,Songlin Ding,Samuel Dingman,Alyse Doperalski,Nadezhda Dotson,Tom Egdorf,Michael S. Fisher,Rebecca de Frates,Emma Garren,Marissa Garwood,Amanda Gary,Nathalie Gaudreault,Keith B. Godfrey,Melissa Gorham,Hong Gu,Caroline Habel,Kristen Hadley,James Harrington,Julie A. Harris,Alex M. Henry,DiJon Hill,Samuel R Josephsen,Sara Kebede,Lisa Kim,Matthew Kroll,Brian Lee,Tracy Lemon,Katherine E. Link,Xiaoxiao Liu,Brian Long,Rusty Mann,Medea McGraw,Stefan Mihalas,Alice Mukora,Gabe J. Murphy,Lindsay Ng,Kiet Ngo,Thuc Nghi Nguyen,Philip R. Nicovich,Aaron Oldre,Daniel Park,Sheana Parry,Jed Perkins,Lydia Potekhina,David Reid,Miranda Robertson,David Sandman,Martin Schroedter,Cliff Slaughterbeck,Gilberto J. Soler-Llavina,Josef Sulc,Aaron Szafer,Bosiljka Tasic,Naz Taskin,Corinne Teeter,Nivretta Thatra,Herman Tung,Wayne Wakeman,Grace Williams,Rob Young,Zhi Zhou,Colin Farrell,Hanchuan Peng,Michael Hawrylycz,Ed Lein,Lydia Ng,Anton Arkhipov,Amy Bernard,John W. Phillips,Hongkui Zeng,Christof Koch +94 more
TL;DR: A single-cell characterization pipeline is established using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions to establish a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features.
Journal ArticleDOI
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.
Zizhen Yao,Cindy T. J. van Velthoven,Thuc Nghi Nguyen,Jeff Goldy,Adriana E. Sedeno-Cortes,Fahimeh Baftizadeh,Darren Bertagnolli,Tamara Casper,Megan Chiang,Kirsten Crichton,Songlin Ding,Olivia Fong,Emma Garren,Alexandra Glandon,Nathan W. Gouwens,James Gray,Lucas T. Graybuck,Michael Hawrylycz,Daniel Hirschstein,Matthew Kroll,Kanan Lathia,Changkyu Lee,Boaz P. Levi,Delissa McMillen,Stephanie Mok,Thanh Pham,Qingzhong Ren,Christine Rimorin,Nadiya V. Shapovalova,Josef Sulc,Susan M. Sunkin,Michael Tieu,Amy Torkelson,Herman Tung,Katelyn Ward,Nick Dee,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng +38 more
TL;DR: The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning as discussed by the authors, and a transcriptomic cell type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types.