M
Michael A. Matthay
Researcher at University of California, San Francisco
Publications - 1063
Citations - 110857
Michael A. Matthay is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 151, co-authored 998 publications receiving 98687 citations. Previous affiliations of Michael A. Matthay include University of California & Cardiovascular Institute of the South.
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Journal ArticleDOI
Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
Michael A. Matthay,Carolyn S. Calfee,Hanjing Zhuo,B. Taylor Thompson,Jennifer G. Wilson,Joseph E. Levitt,Angela J. Rogers,Jeffrey E. Gotts,Jeanine P. Wiener-Kronish,Ednan K. Bajwa,Michael P. Donahoe,Bryan J. McVerry,Luis A. Ortiz,Matthew C. Exline,John W. Christman,Jason Abbott,Kevin L. Delucchi,Lizette Caballero,Melanie McMillan,David H. McKenna,Kathleen D. Liu +20 more
TL;DR: One dose of intravenous MSCs was safe in patients with moderate to severe ARDS, and the viability of M SCs must be improved.
Journal ArticleDOI
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial
Carolyn S. Calfee,Kevin L. Delucchi,Pratik Sinha,Michael A. Matthay,Jonathan Hackett,Manu Shankar-Hari,Manu Shankar-Hari,Cliona McDowell,John G Laffey,John G Laffey,John G Laffey,Cecilia O'Kane,Daniel F. McAuley,Andrew Johnston,Archana Paikray,Cat Yates,Petra Polgarova,Esther Price,Amy McInerney,Katarzyna Zamoscik,Ged Dempsey,Colette Seasman,Lynn Gilfeather,Noel Hemmings,Sinead O'Kane,Paul Johnston,Lukas Pokorny,Chris Nutt,Orla O'Neill,Prashast Prashast,Chris Smalley,Reni Jacob,James O'Rourke,Syed Farjad Sultan,Carole Schilling,Gavin D. Perkins,Teresa Melody,Keith Couper,Ron Daniels,Fang Gao,Julian Hull,Timothy Gould,Matthew Thomas,Katie Sweet,Dorothy Breen,Emer Neau,Willis J Peel,Catherine Jardine,Paul Jefferson,Stephen E Wright,Kayla Harris,Sarah Hierons,John G. Laffey,Veronica McInerney,Luigi Camporota,Katie Lei,Sundeep Kaul,Molly Chibvuri,Andrew Gratrix,Rachael Bennett,Victoria Martinson,Lisa Sleight,Neil Smith,Philip Hopkins,Daniel Hadfield,Sarah Casboult,Fiona Wade-Smith,Julie Dawson,Clare Mellis,Clair Harris,Georgina Parsons,Sinead Helyar,Andrew R Bodenham,Stuart Elliot,Zoe Beardow,Sian Birch,Brian Marsh,Teresa Martin,Akesh Dhrampal,Melissa Rosbergen,Stephen T. Webb,Fiona Bottrill,Henrik Reschreiter,Helena Barcraft-Barnes,Julie Camsooksai,Andrew Johnston,Aisling Clarkson,Conor Bentley,Lauren Cooper,Yongyan Qui,Natalie Mitchell,Ronald Carrera,Arlo Whitehouse,Christopher Danbury,Nicola Jacques,Abby Brown,David Rogerson,Craig Morris,Timothy S. Walsh,Mike Gillies,Grant Price,Kallirroi Kefala,Neil Young,David Hope,Corrienne McCulloch,Jean Antonelli,Pam Ramsay,Kirsty Everingham,Louise Boardman,Heidi Dawson,Fiona Pollock,Joanne Thompson,Ingeborg Welters,Lee Poole,Peter Hampshire,Alison Hall,Karen Williams,Anna Walker,Laura Youds,Samantha Hendry,Victoria Waugh,Julie Patrick-Heselton,David Shaw,Irfan Chaudry,Jacqueline Baldwin,Stephen Drage,Laura Ortiz-Ruiz de Gordoa,Daniel McAuley,Leona Bannon,Vanessa Quinn,Lia McNamee,Griania White,Maurizio Cecconi,Johannes Mellinghoff,Donal Ryan,Alistair Nichol,Banwari Agarwal,Paula Meale,Sarah James,Kulwant Dhadwal,Daniel Martin,Agnieszka Walecka,Stephen G. Ward,John Trinder,Samantha Hagan,Janice Montgomery,Catherine Leonard,Elizabeth Lemon,Tom Trinick,Murthy Buddhavarapu,Geraldine Ward,Christopher Bassford,Alan Davidson,Kate McGuigan,Anissa Benchiheub,Naomi Hickey,Alexander Binning,Steven Henderson,J A Wood,Andrew Burtenshaw,Dawn Kelly,Terry Martin,Jessica Thrush,Julie Wollaston,Stephen Graystone,Gavin Nicol,Gareth Sellors +166 more
TL;DR: Although HARP-2 found no difference in 28-day survival between placebo and simvastatin, significantly different survival was identified across patients stratified by treatment and subphenotype (p<0·0001), and within the hyperinflammatory subphenotypes, patients treated with simVastatin had significantly higher 28- day survival than did those given placebo.
Journal ArticleDOI
Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells IMPLICATION OF NATURAL ANTISENSE HIF-1α
Tokujiro Uchida,Fabrice Rossignol,Michael A. Matthay,Rémi Mounier,Sylvianne Couette,Eric Clottes,Christine Clerici +6 more
TL;DR: Data indicate that, during prolonged hypoxia, HIF-α proteins negatively regulate Hif-1α expression through an increase in aHIF and destabilization of HIF/2α mRNA, which likely conveys target gene specificity.
Journal ArticleDOI
Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
Mark R. Looney,John X. Nguyen,Yongmei Hu,Jessica Van Ziffle,Clifford A. Lowell,Michael A. Matthay +5 more
TL;DR: A 2-step mechanism of TRALI is suggested: priming of hematopoietic cells, followed by vascular deposition of activated neutrophils and platelets that then mediate the severe lung injury.
Journal ArticleDOI
Recent trends in acute lung injury mortality: 1996-2005.
TL;DR: Over the past decade, there seems to be a clear temporal improvement in survival among patients with ALI treated at ARDS Network centers, and the findings strongly suggest that other advancements in critical care, aside from lower tidal volume ventilation, accounted for this improvement in mortality.