M
Michael A. Matthay
Researcher at University of California, San Francisco
Publications - 1063
Citations - 110857
Michael A. Matthay is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 151, co-authored 998 publications receiving 98687 citations. Previous affiliations of Michael A. Matthay include University of California & Cardiovascular Institute of the South.
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Journal ArticleDOI
The lectin-like domain of tumor necrosis factor-α increases membrane conductance in microvascular endothelial cells and peritoneal macrophages
Marusa Hribar,Alain Bloc,F. Gisou van der Goot,Lucie Fransen,Patrick De Baetselier,Georges E. Grau,Horst Bluethmann,Michael A. Matthay,Yves Dunant,Jérôme Pugin,Rudolf Lucas +10 more
TL;DR: It is shown that TNF exerts a pH‐dependent increase in membrane conductance in primary lung microvascular endothelial cells and peritoneal macrophages, and the amiloride sensitivity of the observed activity suggests a binding of TNF to an endogenousion channel rather than channel formation by TNF itself.
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Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.
Mark R. Looney,Nareg Roubinian,Ognjen Gajic,Michael A. Gropper,Rolf D. Hubmayr,Clifford A. Lowell,Peter Bacchetti,Gregory A. Wilson,Monique Koenigsberg,Deanna C. Lee,Ping Wu,Barbara Grimes,Philip J. Norris,Edward L. Murphy,Manish J. Gandhi,Jeffrey L. Winters,David C. Mair,Randy M. Schuller,Nora V. Hirschler,Nora V. Hirschler,Rosa Sanchez Rosen,Michael A. Matthay,Pearl Toy +22 more
TL;DR: Transfusion-related acute lung injury produced a condition resembling the systemic inflammatory response syndrome and was associated with substantial in-hospital morbidity and mortality in patients with transfusion- related acute Lung Injury compared with transfused controls.
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Soluble Transforming Growth Factor-α Is Present in the Pulmonary Edema Fluid of Patients With Acute Lung Injury
TL;DR: Breathtakingly, biologically relevant concentrations of soluble TGF-alpha are present in the pulmonary edema fluid on day 1 of patients with acute lung injury, a remarkable finding with important implications for the repair and resolution of acute lung Injury.
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Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats.
TL;DR: The endogenous release of catecholamines associated with hemorrhagic shock markedly stimulates alveolar fluid clearance by a beta-adrenergic-mediated stimulation of active sodium transport, suggesting a new, previously unrecognized mechanism that may protect against alveolars flooding in the acute phase of hemorrhagicshock.
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Assessment of Prognosis in Patients With Community-Acquired Pneumonia Who Require Mechanical Ventilation
TL;DR: Based on clinical parameters measured over the first 24 h of mechanical ventilation, this model accurately identified critically ill, mechanically ventilated patients with CAP for whom prolonged intensive care may not be of benefit.