Michael A. Matthay

TL;DR: In this group of severely injured trauma patients, the degree of metabolic acidosis at the time of admission identified those patients with the highest probability of developing acute lung injury, and the volume of crystalloid solution administered during the first 24 hrs was significantly greater in patients who later developed acute Lung injury.

TL;DR: Interestingly, in mild-to-moderate lung injury, alveolar edema fluid clearance is often preserved, and multiple pharmacological tools such as beta-adrenergic agonists, vasoactive drugs, or gene therapy may prove effective in stimulating the resolution of alveolars edema in the injured lung.

TL;DR: Alveolar albumin clearance occurs by receptor-mediated transcytosis at low protein concentrations but proceeds by passive paracellular mechanisms at higher concentrations, and Because protein concentrations in pulmonary edema fluid are high, albumin concentrations of 5 g/100 ml or more, clearance of alveolar protein occurs byParacellular pathways in the setting of pulmonary edEMA.

TL;DR: Both plasma and edema fluid levels of sICAM-1 are higher in patients with ALI than in Patients with hydrostatic pulmonary edema, and higher plasma sICam-1 levels and increasing sICams1 levels over time are associated with poor clinical outcomes in ALI.

TL;DR: This rabbit study provides further evidence for important species differences in the basal rates of alveolar liquid and solute clearance as well as the response to beta-adrenergic agonists and ion transport inhibitors.