M
Michael A. Matthay
Researcher at University of California, San Francisco
Publications - 1063
Citations - 110857
Michael A. Matthay is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 151, co-authored 998 publications receiving 98687 citations. Previous affiliations of Michael A. Matthay include University of California & Cardiovascular Institute of the South.
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Journal ArticleDOI
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
Brian J. Anderson,Carolyn S. Calfee,Kathleen D. Liu,John P. Reilly,Kirsten N. Kangelaris,Michael G.S. Shashaty,Aili L. Lazaar,Aili L. Lazaar,Andrew I. Bayliffe,Robert Gallop,Robert Gallop,Todd A. Miano,Thomas G. Dunn,Erik Johansson,Jason Abbott,Alejandra Jauregui,Thomas Deiss,Kathryn Vessel,Annika Belzer,Hanjing Zhuo,Michael A. Matthay,Nuala J. Meyer,Jason D. Christie +22 more
TL;DR: Using sTNFR1 or IL8 to select high-risk patients improved clinical trial power and efficiency compared to selecting patients with septic shock and Ang2 did not outperform septicshock as an enrichment factor.
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The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia.
Naveen Gupta,Naveen Gupta,Ranjeet Kumar Sinha,Anna Krasnodembskaya,Xiao Xu,Victor Nizet,Michael A. Matthay,John H. Griffin,John H. Griffin +8 more
TL;DR: It is demonstrated that both TLR4 and PAR1 are required for MSC survival under inflammatory conditions in vitro and therapeutic capacity in vivo, and that theTLR4 pathway regulates signaling through PAR1 on MSCs.
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Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome.
Jehan Alladina,Sean D. Levy,Kathryn A. Hibbert,James L. Januzzi,R. Scott Harris,Michael A. Matthay,B. Taylor Thompson,Ednan K. Bajwa +7 more
TL;DR: Higher soluble suppression of tumorigenicity-2 and interleukin-6 concentrations are each associated with worse outcomes during weaning of mechanical ventilation and increased need for reintubation in patients with acute respiratory distress syndrome.
Journal ArticleDOI
Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
Shuo Liu,Shuo Liu,Chunxue Wang,Gary M. Green,Hanjing Zhuo,Kathleen D. Liu,Kirsten N. Kangelaris,Antonio Gomez,Alejandra Jauregui,Kathryn Vessel,Serena Ke,Carolyn M. Hendrickson,Michael A. Matthay,Carolyn S. Calfee,Lorraine B. Ware,Paul J. Wolters +15 more
TL;DR: Short PBL-TL is strongly associated with worse survival and more severe ARDS in critically ill patients, especially patients with sepsis, and the findings suggest that telomere dysfunction may contribute to outcomes from critical illness.
Journal ArticleDOI
Bone Marrow-Derived Cells Participate in Stromal Remodeling of the Lung Following Acute Bacterial Pneumonia in Mice
Vladimir B. Serikov,Vladimir B. Serikov,Viatcheslav M. Mikhaylov,Anna D. Krasnodembskay,Michael A. Matthay +4 more
TL;DR: The data suggest that following 5-Gy irradiation and acute bacterial pneumonia, BMDC may temporarily participate in lung postinflammatory repair and stromal remodeling without long-term engraftment as specialized endothelial or epithelial cells.