M
Michael A. Matthay
Researcher at University of California, San Francisco
Publications - 1063
Citations - 110857
Michael A. Matthay is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 151, co-authored 998 publications receiving 98687 citations. Previous affiliations of Michael A. Matthay include University of California & Cardiovascular Institute of the South.
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Journal ArticleDOI
Pathogenesis of Acute Respiratory Distress Syndrome
TL;DR: The goal of this review is to describe the current understanding of the pathogenesis and pathophysiology of ARDS, and explain how clinical trials and preclinical studies of novel therapeutic agents have further refined this understanding.
Journal ArticleDOI
Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults
Charles Langelier,Katrina Kalantar,Farzad Moazed,Michael R. Wilson,Emily D. Crawford,Thomas Deiss,Annika Belzer,Samaneh Bolourchi,Saharai Caldera,Monica Fung,Alejandra Jauregui,Katherine Malcolm,Amy Lyden,Lillian M. Khan,Kathryn Vessel,Jenai Quan,Matt S. Zinter,Charles Y. Chiu,Eric D. Chow,Jenny L. Wilson,Steve Miller,Michael A. Matthay,Katherine S. Pollard,Katherine S. Pollard,Stephanie A. Christenson,Carolyn S. Calfee,Joseph L. DeRisi +26 more
TL;DR: It is suggested that a single streamlined protocol offering an integrated genomic portrait of pathogen, microbiome, and host transcriptome may hold promise as a tool for LRTI diagnosis.
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Protein C and thrombomodulin in human acute lung injury.
TL;DR: The protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes and may be a potential therapeutic target in patientsWithdrawal from sepsis or acute respiratory distress syndrome is associated with death, fewer ventilator-free days, and more nonpulmonary organ failures.
Journal ArticleDOI
Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers
Murali Shyamsundar,Scott McKeown,Cecilia O'Kane,Thelma R. Craig,Vanessa Brown,David R Thickett,Michael A. Matthay,Clifford C. Taggart,Janne T. Backman,J. Stuart Elborn,Daniel F. McAuley +10 more
TL;DR: Simvastatin has antiinflammatory effects in the pulmonary and systemic compartment in humans exposed to inhaled LPS.
Journal ArticleDOI
Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung
Leland G. Dobbs,Robert F. Gonzalez,Michael A. Matthay,Ethan P. Carter,Lennell Allen,Alan S. Verkman +5 more
TL;DR: The purpose of this study was to test whether osmotic water permeability in type I alveolar epithelial cells is high enough to account for the high Pf of the intact lung.