M
Michael A. Matthay
Researcher at University of California, San Francisco
Publications - 1063
Citations - 110857
Michael A. Matthay is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 151, co-authored 998 publications receiving 98687 citations. Previous affiliations of Michael A. Matthay include University of California & Cardiovascular Institute of the South.
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Journal ArticleDOI
Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits
TL;DR: Monensin- and nocodazole-sensitive protein-uptake pathways do not account for most alveolar protein clearance when the distal air spaces are filled with a protein solution, suggesting that the inhibitors disrupted microtubules or interrupted cellular membrane traffic in the lung.
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A Novel Tumor Necrosis Factor–mediated Mechanism of Direct Epithelial Sodium Channel Activation
Istvan Czikora,Abdel A. Alli,Hui-Fang Bao,David Kaftan,Supriya Sridhar,Hans-Jürgen Apell,Boris A. Gorshkov,Richard E. White,Astrid Zimmermann,Albrecht Wendel,Meike Pauly-Evers,Jürg Hamacher,Jürg Hamacher,Irène Garcia-Gabay,Bernhard Fischer,Alexander D. Verin,Zsolt Bagi,Jean-Francois Pittet,Waheed Shabbir,Rosa Lemmens-Gruber,Trinad Chakraborty,Ahmed Lazrak,Michael A. Matthay,Douglas C. Eaton,Rudolf Lucas +24 more
TL;DR: A novel TNF-mediated mechanism of direct ENaC activation is demonstrated and a physiological role for the lectin-like domain of TNF in the resolution of alveolar edema during inflammation is indicated.
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Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine
Tsutomu Sakuma,Xiu Gu,Zheng Wang,Sumiko Maeda,Makoto Sugita,Motoyasu Sagawa,Kazuhiro Osanai,Hirohisa Toga,Lorraine B. Ware,G. Folkesson,Michael A. Matthay +10 more
TL;DR: Exogenous cyclic adenosine monophosphate-dependent stimulation will probably be required to accelerate the resolution of alveolar edema in the lungs of patients with pulmonary edema, and administration of exogenous catecholamines into the distal airspaces can stimulateAlveolar fluid clearance in the human lung.
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Targeted transgenic expression of β2-adrenergic receptors to type II cells increases alveolar fluid clearance
Dennis W. McGraw,Norimasa Fukuda,Paul F. James,Susan L. Forbes,Alison L. Woo,Jerry B. Lingrel,David P. Witte,Michael A. Matthay,Stephen B. Liggett +8 more
TL;DR: Findings show that beta( 2)-AR overexpression can be an effective means to increase AFC in the absence of exogenous agonists and that AFC can be stimulated by activation of beta(2)-ARs specifically expressed on ATII cells.
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Higher urine desmosine levels are associated with mortality in patients with acute lung injury
Dana E. McClintock,Barry Starcher,Mark D. Eisner,B. Taylor Thompson,Doug Hayden,Gwynne D. Church,Michael A. Matthay +6 more
TL;DR: Patients with acute lung injury ventilated with lower tidal volumes have lower urine desmosine levels, a finding that may reflect reduced extracellular matrix breakdown.