M
Michael A. Matthay
Researcher at University of California, San Francisco
Publications - 1063
Citations - 110857
Michael A. Matthay is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 151, co-authored 998 publications receiving 98687 citations. Previous affiliations of Michael A. Matthay include University of California & Cardiovascular Institute of the South.
Papers
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Journal ArticleDOI
Phenotypes and personalized medicine in the acute respiratory distress syndrome.
Michael A. Matthay,Yaseen M. Arabi,Emily R. Siegel,Lorraine B. Ware,Lieuwe D. J. Bos,Pratik Sinha,Jeremy R. Beitler,Katherine D. Wick,Martha A. Q. Curley,Jean-Michel Constantin,Joseph E. Levitt,Carolyn S. Calfee +11 more
TL;DR: This review focuses on classifying ARDS by the associated clinical disorders, physiological data, and radiographic imaging, and considers biologic phenotypes, including plasma protein biomarkers, gene expression, and common causative microbiologic pathogens.
Journal ArticleDOI
Diagnostic workup for ARDS patients
Laurent Papazian,Carolyn S. Calfee,Davide Chiumello,Charles Edouard Luyt,Nuala J. Meyer,Hiroshi Sekiguchi,Michael A. Matthay,Gianfranco Umberto Meduri +7 more
TL;DR: The definition of ARDS remains clinical and the main objective of the diagnostic workup should be to be focused on identification of its aetiology, especially a treatable infection.
Journal ArticleDOI
Novel Role of the Human Alveolar Epithelium in Regulating Intra-Alveolar Coagulation
Ling Wang,Julie A. Bastarache,Nancy Wickersham,Xiaohui Fang,Michael A. Matthay,Lorraine B. Ware +5 more
TL;DR: New evidence is provided that the alveolar epithelium can modulate the protein C pathway and thus could be an important determinant ofAlveolar fibrin deposition, a fundamental mechanism for the lung to localize and confine injury, thus limiting the risk of dissemination of injury or infection to the systemic circulation.
Journal ArticleDOI
Secondary peritonitis: principles of diagnosis and intervention
TL;DR: The pathophysiology of peritonitis and its potential progression to sepsis is reviewed, the utility and limitations of the physical examination and laboratory and radiographic tests are discussed, and a paradigm for the management of secondaryPeritonitis is presented.
Journal ArticleDOI
Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma
Jason D. Christie,Mark M. Wurfel,Rui Feng,Grant E. O'Keefe,Jonathan P. Bradfield,Lorraine B. Ware,David C. Christiani,Carolyn S. Calfee,Mitchell J. Cohen,Michael A. Matthay,Nuala J. Meyer,Cecilia Kim,Mingyao Li,Joshua M. Akey,Kathleen C. Barnes,Jonathan E. Sevransky,Paul N. Lanken,Addison K. May,Richard Aplenc,James P. Maloney,Hakon Hakonarson +20 more
TL;DR: This study supports the feasibility of future multi-center GWA investigations of ALi risk, and identifies PPFIA1 as a potential functional candidate ALI risk gene for future research.