M
Michael A. Matthay
Researcher at University of California, San Francisco
Publications - 1063
Citations - 110857
Michael A. Matthay is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 151, co-authored 998 publications receiving 98687 citations. Previous affiliations of Michael A. Matthay include University of California & Cardiovascular Institute of the South.
Papers
More filters
Journal ArticleDOI
Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome
TL;DR: The possible contribution of metabolites of arachidonic acid to the increased permeability of the alveolar-capillary barrier in the adult respiratory distress syndrome was examined by quantifying the pulmonary edema fluid concentrations of lipoxygenase and cyclooxygenases products.
Journal ArticleDOI
Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome
Lorraine B. Ware,Tatsuki Koyama,Zhiguo Zhao,David R. Janz,Nancy Wickersham,Gordon R. Bernard,Addison K. May,Carolyn S. Calfee,Michael A. Matthay +8 more
TL;DR: Altered levels of plasma biomarkers may be useful biologic confirmation of the diagnosis of ARDS in patients with sepsis, and also potentially for selecting patients for clinical trials that are designed to reduce lung epithelial injury.
Journal ArticleDOI
Global absence and targeting of protective immune states in severe COVID-19.
Alexis J. Combes,Tristan Courau,Nicholas F. Kuhn,Kenneth H. Hu,Arja Ray,William S. Chen,Nayvin W. Chew,Simon J. Cleary,Divyashree Kushnoor,Gabriella C Reeder,Alan Shen,Jessica Tsui,Kamir J Hiam-Galvez,Priscila Muñoz-Sandoval,Wandi S Zhu,David Lee,Yang Sun,Ran You,Mélia Magnen,Lauren Rodriguez,Kwok W. Im,Nina K. Serwas,Aleksandra Leligdowicz,Colin R. Zamecnik,Rita P. Loudermilk,Michael R. Wilson,Chun Jimmie Ye,Gabriela K. Fragiadakis,Mark R. Looney,Vincent Chan,Alyssa Ward,Sidney A. Carrillo,Michael A. Matthay,David J. Erle,Prescott G. Woodruff,Charles Langelier,Kirsten N. Kangelaris,Carolyn M. Hendrickson,Carolyn S. Calfee,Arjun A. Rao,Matthew F. Krummel +40 more
TL;DR: In this article, the authors performed a whole-blood-preserving single-cell analysis protocol to integrate contributions from all major immune cell types of the blood, including neutrophils, monocytes, platelets, lymphocytes and the contents of the serum.
Journal ArticleDOI
Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
Harold R. Collard,Carolyn S. Calfee,Paul J. Wolters,Jin Woo Song,Sang-Bum Hong,Sandra Brady,Akitoshi Ishizaka,Kirk D. Jones,Talmadge E. King,Michael A. Matthay,Dong Soon Kim +10 more
TL;DR: The hypothesis that type II alveolar epithelial cells are centrally involved in the pathobiology of acute exacerbation of idiopathic pulmonary fibrosis is supported and the hypothesis that acute exacerbations of IPF has a distinct plasma biomarker profile from that of acute lung injury is suggested.
Journal ArticleDOI
Pharmacotherapy of Acute Lung Injury and the Acute Respiratory Distress Syndrome
Magda Cepkova,Michael A. Matthay +1 more
TL;DR: An overview of pharmacological therapies of acute lung injury and the acute respiratory distress syndrome tested in clinical trials and current recommendations for their use are provided as well as a discussion of potential future pharmacology therapies including β2-adrenergic agonist therapy, keratinocyte growth factor, and activated protein C.