M
Michael J. Caulfield
Researcher at International AIDS Vaccine Initiative
Publications - 63
Citations - 5715
Michael J. Caulfield is an academic researcher from International AIDS Vaccine Initiative. The author has contributed to research in topics: Antigen & DNA vaccination. The author has an hindex of 32, co-authored 63 publications receiving 5483 citations. Previous affiliations of Michael J. Caulfield include Merck & Co. & United States Military Academy.
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Journal ArticleDOI
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.
John W. Shiver,Tong-Ming Fu,Ling Chen,Danilo R. Casimiro,Mary-Ellen Davies,Robert K. Evans,Zhiqiang Zhang,Adam J. Simon,Wendy L. Trigona,Sheri Dubey,Lingyi Huang,Virginia Harris,Romnie Long,Xiaoping Liang,Larry Handt,William A. Schleif,Lan Zhu,Daniel C. Freed,Natasha Persaud,Liming Guan,Kara Punt,Aimin Tang,Minchun Chen,Keith A. Wilson,Kelly B. Collins,Gwendolyn J. Heidecker,V. Rose Fernandez,Helen C. Perry,Joseph G. Joyce,Karen M. Grimm,James C. Cook,Paul M. Keller,Denise S. Kresock,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,Zheng Xu,Kathryn E. Bohannon,David B. Volkin,David C. Montefiori,Ayako Miura,Georgia R. Krivulka,Michelle A. Lifton,Marcelo J. Kuroda,Jörn E. Schmitz,Norman L. Letvin,Michael J. Caulfield,Andrew J. Bett,Rima Youil,David C. Kaslow,Emilio A. Emini +51 more
TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
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Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
Danilo R. Casimiro,Ling Chen,Tong-Ming Fu,Robert K. Evans,Michael J. Caulfield,Mary-Ellen Davies,Aimin Tang,Minchun Chen,Lingyi Huang,Virginia Harris,Daniel C. Freed,Keith A. Wilson,Sheri Dubey,De-Min Zhu,Denise K. Nawrocki,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,William M. Hurni,Zheng Xu,Jeffrey G. Smith,Su Wang,Xu Liu,Liming Guan,Romnie Long,Wendy L. Trigona,Gwendolyn J. Heidecker,Helen C. Perry,Natasha Persaud,Timothy J. Toner,Qin Su,Xiaoping Liang,Rima Youil,Michael Chastain,Andrew J. Bett,David B. Volkin,Emilio A. Emini,John W. Shiver +38 more
TL;DR: Results are suggestive of an immunization strategy for humans that is centered on use of the adenovirus vector and in which existing adenavirus immunity may be overcome by combined immunization with adjuvanted DNA and adenvirus vector boosting.
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Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
Leopold Kong,Jeong Hyun Lee,Katie J. Doores,Katie J. Doores,Katie J. Doores,Charles D. Murin,Jean-Philippe Julien,Jean-Philippe Julien,Ryan McBride,Yan Liu,Andre J. Marozsan,Albert Cupo,Per Johan Klasse,Simon Hoffenberg,Michael J. Caulfield,C. Richter King,Yuanzi Hua,Yuanzi Hua,Khoa Le,Khoa Le,Reza Khayat,Marc C. Deller,Thomas Clayton,Henry Tien,Ten Feizi,Rogier W. Sanders,Rogier W. Sanders,James C. Paulson,John P. Moore,Robyn L. Stanfield,Robyn L. Stanfield,Dennis R. Burton,Andrew B. Ward,Andrew B. Ward,Ian A. Wilson +34 more
TL;DR: Combined structural studies of PGT 135, PGT 128 and 2G12 show that this Asn332-dependent antigenic region is highly accessible and much more extensive than initially appreciated, which allows for multiple binding modes and varied angles of approach; thereby it represents a supersite of vulnerability for antibody neutralization.
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Varicella-Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine
Myron J. Levin,Michael N. Oxman,Jane H. Zhang,Gary R. Johnson,Harold A. Stanley,A. R Hayward,Michael J. Caulfield,Michael R. Irwin,Jeffrey G. Smith,Jim Clair,Ivan S. F. Chan,Heather M. Williams,Ruth Harbecke,Rocio D. Marchese,Sharon E. Straus,Anne A. Gershon,Adriana Weinberg +16 more
TL;DR: The hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia is supported, as it paralleled the clinical effects of the vaccine observed during the efficacy trial.
Journal ArticleDOI
Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes.
Tong-Ming Fu,Jeffrey B. Ulmer,Michael J. Caulfield,R. Randall Deck,Arthur Friedman,Su Wang,Xu Liu,John J. Donnelly,Margaret A. Liu +8 more
TL;DR: Investigating the role of muscle cells and involvement of professional antigen-presenting cells (APCs) in priming CTL responses following DNA vaccination found expression of antigen by muscle cells in BM chimeric mice after myoblast transplantation is sufficient to induce CTL restricted only by the MHC haplotype of the donor BM, indicating that transfer of antigen from myocytes to professional APCs can occur.