M
Michael R. Edwards
Researcher at National Institutes of Health
Publications - 164
Citations - 10111
Michael R. Edwards is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rhinovirus & Asthma. The author has an hindex of 46, co-authored 158 publications receiving 8887 citations. Previous affiliations of Michael R. Edwards include Imperial College Healthcare & University of Bern.
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Journal ArticleDOI
Role of deficient type III interferon-λ production in asthma exacerbations
Marco Contoli,Simon D. Message,Vasile Laza-Stanca,Michael R. Edwards,Peter A. B. Wark,Peter A. B. Wark,Nathan W. Bartlett,Tatiana Kebadze,Patrick Mallia,Luminita A. Stanciu,Hayley L. Parker,Louise Slater,Anita Lewis-Antes,Onn Min Kon,Stephen T. Holgate,Donna E. Davies,Sergei V. Kotenko,Alberto Papi,Sebastian L. Johnston +18 more
TL;DR: In this paper, the authors show deficient induction of interferon-λs by rhinovirus in primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus induced asthma exacerbation and virus load in experimentally infected human volunteers.
Journal ArticleDOI
The Airway Epithelium: Soldier in the Fight against Respiratory Viruses
TL;DR: The airway epithelium acts as a frontline defense against respiratory viruses, not only as a physical barrier and through the mucociliary apparatus but also through its immunological functions, which initiates multiple innate and adaptive immune mechanisms which are crucial for efficient antiviral responses.
Journal ArticleDOI
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
David A. Jackson,David A. Jackson,Heidi Makrinioti,Batika M. J. Rana,Betty Shamji,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Joseph Footitt,Joseph Footitt,Jerico del-Rosario,Jerico del-Rosario,Aurica G. Telcian,A A Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,Jaideep Dhariwal,James D. Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A. Stanciu,Musa Khaitov,Nathan W. Bartlett,Michael R. Edwards,Onn Min Kon,Patrick Mallia,Patrick Mallia,Nikolaos G. Papadopoulos,Cezmi A. Akdis,John Westwick,Matthew J. Edwards,David J. Cousins,Ross P. Walton,Sebastian L. Johnston,Sebastian L. Johnston +38 more
TL;DR: IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Journal ArticleDOI
Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation
Patrick Mallia,Simon D. Message,V Gielen,Marco Contoli,Katrina Gray,Tatiana Kebadze,Julia Aniscenko,Vasile Laza-Stanca,Michael R. Edwards,Louise Slater,Alberto Papi,Luminita A. Stanciu,Onn Min Kon,Malcolm Johnson,Sebastian L. Johnston +14 more
TL;DR: A new model of COPD exacerbation is developed that strongly supports a causal relationship between rhinovirus infection and COPD alleviation and impaired IFN production and neutrophilic inflammation may be important mechanisms in virus-induced COPd exacerbations.
Journal ArticleDOI
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
Nathan W. Bartlett,Ross P. Walton,Michael R. Edwards,Juliya Aniscenko,Gaetano Caramori,Jie Zhu,Nicholas Glanville,Katherine Choy,Patrick Jourdan,Jerome Burnet,Tobias J. Tuthill,Michael S Pedrick,Michael Hurle,Chris Plumpton,Nigel A. Sharp,James N Bussell,Dallas M. Swallow,Jürgen Schwarze,Bruno Guy,Jeffrey Almond,Peter K. Jeffery,Clare M. Lloyd,Alberto Papi,R. A. Killington,David J. Rowlands,Edward D. Blair,Neil J. Clarke,Sebastian L. Johnston +27 more
TL;DR: Three novel mouse models of rhinovirus infection have features similar to those observed in rhinvirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations.