Robert Fagard

TL;DR: The extended follow-up of Syst-Eur patients reinforces the evidence that blood pressure–lowering therapy initiated with a long-acting dihydropyridine protects against dementia in older patients with systolic hypertension.

TL;DR: The requirements and the methodological issues to be addressed for using ABPM in clinical practice are addressed, the clinical indications for ABPM suggested by the available studies are outlined in detail, and the place of home measurement of blood pressure in relation to ABPM is discussed.

TL;DR: Reduction of blood pressure produces benefits in younger and older adults, with no strong evidence that protection against major vascular events afforded by different drug classes varies substantially with age.

TL;DR: Results of a large-scale specific trial are needed for definite conclusion that antihypertensive treatment is beneficial in very elderly hypertensive patients, as an age threshold beyond which hypertension should not be treated cannot be justified.

TL;DR: It is concluded that nighttime blood pressure is in general a better predictor of outcome than daytime pressure in hypertensive patients, and the night–day blood pressure ratio predicts mortality, even after adjustment for 24-hour blood pressure.