R
Ronald Klein
Researcher at University of Wisconsin-Madison
Publications - 1306
Citations - 163459
Ronald Klein is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Population & Diabetes mellitus. The author has an hindex of 194, co-authored 1305 publications receiving 149140 citations. Previous affiliations of Ronald Klein include Los Angeles Biomedical Research Institute & Wake Forest University.
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Journal ArticleDOI
Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in patients with severe nonproliferative or non-high-risk proliferative diabetic retinopathy: a randomized clinical trial
Ingrid U. Scott,Ingrid U. Scott,Gregory R. Jackson,David A. Quillen,Michael Larsen,Michael Larsen,Ronald Klein,Jason Liao,Stig K. Holfort,Inger Christine Munch,Thomas W. Gardner +10 more
TL;DR: Oral doxycycline may be a promising therapeutic strategy targeting the inflammatory component of DR and FDP, which primarily measures inner retinal function, is responsive to intervention and may beA useful clinical trial end point for proof-of-concept studies in patients with DR.
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A Prospective Cohort Study of Retinal Arteriolar Narrowing and Mortality
TL;DR: Results were largely similar in analyses of cause-specific mortality and in subgroups stratified by age, gender, and diabetes and hypertension status, suggesting that further research is needed to understand the systemic associations of retinal microvascular changes.
Journal Article
The trk family of oncogenes and neurotrophin receptors.
TL;DR: The trk proto-oncogene, non-muscle tropomyosin and tpr map in the long arm of chromosome 1, therefore, trk oncogenes are likely to result from internal rearrangements or from unequal cross-overs between two chromosome 1s.
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Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration
Rinki Ratnapriya,Xiaowei Zhan,Robert N. Fariss,Kari Branham,David Zipprer,Christina Chakarova,Yuri V. Sergeev,Maria M Campos,Mohammad Othman,James S. Friedman,Arvydas Maminishkis,Naushin Waseem,Matthew Brooks,Harsha Rajasimha,Albert O. Edwards,Andrew J. Lotery,Barbara E.K. Klein,Barbara Truitt,Bingshan Li,Debra A. Schaumberg,Debra A. Schaumberg,Denise J. Morgan,Margaux A. Morrison,Eric H Souied,Evangelia E. Tsironi,Felix Grassmann,Gerald A. Fishman,Giuliana Silvestri,Hendrik P. N. Scholl,Ivana K. Kim,Jacqueline Ramke,Jingsheng Tuo,Joanna E. Merriam,John C. Merriam,Kyu Hyung Park,Lana M. Olson,Lindsay A. Farrer,Matthew P. Johnson,Neal S. Peachey,Neal S. Peachey,Mark Lathrop,Robert V. Baron,Robert P. Igo,Ronald Klein,Stephanie A. Hagstrom,Yoichiro Kamatani,Tammy M. Martin,Yingda Jiang,Yvette P. Conley,José Sahel,Donald J. Zack,Chi-Chao Chan,Margaret A. Pericak-Vance,Samuel G. Jacobson,Michael B. Gorin,Michael L. Klein,Rando Allikmets,Sudha K. Iyengar,Bernhard H. F. Weber,Jonathan L. Haines,Thierry Léveillard,Margaret M. DeAngelis,Dwight Stambolian,Daniel E. Weeks,Shomi S. Bhattacharya,Emily Y. Chew,John R. Heckenlively,Gonçalo R. Abecasis,Anand Swaroop +68 more
TL;DR: It appears that rare and common variants in a single gene--FBN2--can contribute to Mendelian and complex forms of macular degeneration and the importance of studying orphan diseases for understanding more common clinical phenotypes is established.
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The association of alcohol consumption with the incidence and progression of diabetic retinopathy.
TL;DR: Alcohol consumption in moderation (< or = 1 oz/day) does not appear to affect the occurrence of diabetic retinopathy.