Ronald Klein

TL;DR: This study extends previous genome-wide association study results using 24 000+ multiethnic participants from 7 discovery cohorts and 5000+ subjects of European ancestry from 2 replication cohorts to investigate the association of single-nucleotide polymorphisms and variants collectively across genes with summary measures of retinal vessel diameters, referred to as the central retinal venule equivalent and thecentral retinal arteriole equivalent.

TL;DR: The data indicate that loss of NNT increases vascular ROS production and exacerbates atherosclerotic plaque development.

TL;DR: Prevalence of AMD will increase substantially by 2050, but the use of new therapies can mitigate its effects, according to the forecast of the Vision Health Cost-Effectiveness Study Group.

TL;DR: Most risk factors associated with self reported glaucoma in people with diabetes cannot currently be modified to decrease incidence and may be particularly in need of specialised ophthalmic observation.

TL;DR: Pan-tissue and GrimAge were higher whereas Skin & Blood and PhenoAge were lower than chronological age and DNAm age was not associated with the risk of CVD or retinopathy over 18–20 years after DNAm measurement.