R
Ronald Klein
Researcher at University of Wisconsin-Madison
Publications - 1306
Citations - 163459
Ronald Klein is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Population & Diabetes mellitus. The author has an hindex of 194, co-authored 1305 publications receiving 149140 citations. Previous affiliations of Ronald Klein include Los Angeles Biomedical Research Institute & Wake Forest University.
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Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error
Dwight Stambolian,Robert Wojciechowski,Robert Wojciechowski,Konrad Oexle,Mario Pirastu,Xiaohui Li,Leslie J. Raffel,Mary Frances Cotch,Emily Y. Chew,Barbara E.K. Klein,Ronald Klein,Tien Yin Wong,Tien Yin Wong,Claire L. Simpson,Caroline C W Klaver,Cornelia M. van Duijn,Virginie J. M. Verhoeven,Paul N. Baird,Veronique Vitart,Andrew D. Paterson,Paul Mitchell,Seang-Mei Saw,Maurizio Fossarello,Krista L. Kazmierkiewicz,Federico Murgia,Laura Portas,Maria Schache,Andrea J. Richardson,Jing Xie,Jie Jin Wang,Jie Jin Wang,Elena Rochtchina,Dcct,Ananth C. Viswanathan,Caroline Hayward,Alan F. Wright,Ozren Polasek,Harry Campbell,Igor Rudan,Ben A. Oostra,André G. Uitterlinden,Albert Hofman,Fernando Rivadeneira,Najaf Amin,Lennart C. Karssen,Johannes R. Vingerling,Seyed Mostafa Hosseini,Angela Döring,Thomas Bettecken,Zoran Vatavuk,Christian Gieger,H.-Erich Wichmann,James F. Wilson,Brian Fleck,Brian Fleck,Paul J. Foster,Fotis Topouzis,Peter McGuffin,Xueling Sim,Michael Inouye,Elizabeth G. Holliday,John Attia,Rodney J. Scott,Jerome I. Rotter,Thomas Meitinger,Joan E. Bailey-Wilson +65 more
TL;DR: A new genome-wide significant locus on chromosome 16 is identified within the RBFOX1 gene which is a neuron-specific splicing factor regulating a wide range of alternative splicing events implicated in neuronal development and maturation, including transcription factors, other splicing factors and synaptic proteins.
Journal ArticleDOI
Arterial compliance and retinal vascular caliber in cerebrovascular disease.
Ning Cheung,F.M. Amirul Islam,David R. Jacobs,David R. Jacobs,A. Richey Sharrett,Ronald Klein,Joseph F. Polak,Mary Frances Cotch,Barbara E.K. Klein,Pamala Ouyang,Tien Yin Wong,Tien Yin Wong +11 more
TL;DR: The relationship between arterial stiffness and retinal vascular caliber is examined and it is found that arterIAL stiffness is a newly recognized risk factor for stroke.
Journal ArticleDOI
How many steps of progression of diabetic retinopathy are meaningful? The Wisconsin epidemiologic study of diabetic retinopathy.
TL;DR: It seems that 1 or more or 2 or more steps of progression of retinopathy over a 4-year period strongly predict the development of PDR over the next 6 years, which would result in the need for fewer subjects or shorter follow-up in some clinical trials.
Journal ArticleDOI
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study1
James H. Schick,Sudha K. Iyengar,B. E. K. Klein,Ronald Klein,K. Reading,Rachel Liptak,Christopher Millard,Kristine E. Lee,Sandra C. Tomany,E.L. Moore,Bonnie A. Fijal,Robert C. Elston +11 more
TL;DR: This work genotyped a subset of subjects from the Beaver Dam (WI) Eye Study and performed a model-free genomewide linkage analysis for markers linked to a quantitative measure of age-related maculopathy, finding that a 14-cM region on chromosome 12, near D12S346, showed the strongest indication of linkage.
Journal ArticleDOI
Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations.
Jie Jin Wang,Jie Jin Wang,Gabriëlle H.S. Buitendijk,Elena Rochtchina,Kristine E. Lee,Barbara E.K. Klein,Cornelia M. van Duijn,Victoria M Flood,Stacy M. Meuer,John Attia,John Attia,Chelsea E. Myers,Elizabeth G. Holliday,Ava Grace Tan,Wayne Smith,Wayne Smith,Sudha K. Iyengar,Paulus T. V. M. de Jong,Albert Hofman,Johannes R. Vingerling,Paul Mitchell,Ronald Klein,Caroline C W Klaver +22 more
TL;DR: Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions.