Showing papers by "Samuel Hellman published in 2015"
Mayo Clinic1, University of Texas MD Anderson Cancer Center2, University of Michigan3, University of Washington4, University of California, San Diego5, Stanford University6, Boston University7, University of Rochester8, Harvard University9, Rutgers University10, University of Alabama at Birmingham11, University of Southern California12, Oregon Health & Science University13, Ohio State University14, City of Hope National Medical Center15, Indiana University – Purdue University Indianapolis16, Georgetown University17, Memorial Sloan Kettering Cancer Center18, University of Chicago19, Thomas Jefferson University20, Emory University21, Fred Hutchinson Cancer Research Center22, New York University23, University of Texas Health Science Center at Houston24, University of Oklahoma25, University of São Paulo26, Icahn School of Medicine at Mount Sinai27, Medical College of Wisconsin28, Temple University29, Stony Brook University30, University of Paris31, Cancer Treatment Centers of America32, Case Western Reserve University33, Children's Hospitals and Clinics of Minnesota34, University of California, Irvine35, Yeshiva University36, University of Utah37, Northwestern University38, University of California, San Francisco39, Florida International University40, Scripps Health41, Cornell University42, Wayne State University43, Cleveland Clinic44, University of Toronto45, Seattle Cancer Care Alliance46, University of Nebraska Medical Center47, National Foundation for Cancer Research48
TL;DR: Tefferi, Ayalew, Kantarjian, Hagop, Rajkumar, S Vincent, Baker, Lawrence H; Abkowitz, Jan L; Adamson, John W; Advani, Ranjana Hira; Antman, Karen H;Antman, John C; Bennett, John M; Benz, Edward J; Berliner, Nancy; Bertino, Joseph; Bhatia, Ravi; Bhattacharya, Smita; Bhojwani, Deepa; Blanke, Charles D; Bloomfield, Clara
Abstract: Author(s): Tefferi, Ayalew; Kantarjian, Hagop; Rajkumar, S Vincent; Baker, Lawrence H; Abkowitz, Jan L; Adamson, John W; Advani, Ranjana Hira; Allison, James; Antman, Karen H; Bast, Robert C; Bennett, John M; Benz, Edward J; Berliner, Nancy; Bertino, Joseph; Bhatia, Ravi; Bhatia, Smita; Bhojwani, Deepa; Blanke, Charles D; Bloomfield, Clara D; Bosserman, Linda; Broxmeyer, Hal E; Byrd, John C; Cabanillas, Fernando; Canellos, George Peter; Chabner, Bruce A; Chanan-Khan, Asher; Cheson, Bruce; Clarkson, Bayard; Cohn, Susan L; Colon-Otero, Gerardo; Cortes, Jorge; Coutre, Steven; Cristofanilli, Massimo; Curran, Walter J; Daley, George Q; DeAngelo, Daniel J; Deeg, H Joachim; Einhorn, Lawrence H; Erba, Harry P; Esteva, Francisco J; Estey, Elihu; Fidler, Isaiah J; Foran, James; Forman, Stephen; Freireich, Emil; Fuchs, Charles; George, James N; Gertz, Morie A; Giralt, Sergio; Golomb, Harvey; Greenberg, Peter; Gutterman, Jordan; Handin, Robert I; Hellman, Samuel; Hoff, Paulo Marcelo; Hoffman, Ronald; Hong, Waun Ki; Horowitz, Mary; Hortobagyi, Gabriel N; Hudis, Clifford; Issa, Jean Pierre; Johnson, Bruce Evan; Kantoff, Philip W; Kaushansky, Kenneth; Khayat, David; Khuri, Fadlo R; Kipps, Thomas J; Kripke, Margaret; Kyle, Robert A; Larson, Richard A; Lawrence, Theodore S; Levine, Ross; Link, Michael P; Lippman, Scott M; Lonial, Sagar; Lyman, Gary H; Markman, Maurie; Mendelsohn, John; Meropol, Neal J; Messinger, Yoav; Mulvey, Therese M; O'Brien, Susan; Perez-Soler, Roman; Pollock, Raphael; Prchal, Josef
135 citations
TL;DR: Understanding the role of microRNAs expressed in oligometastases may lead to improved identification of and interventions for patients with curable metastatic disease, as well as an improved understanding of the molecular basis of this unique clinical entity.
Abstract: Oligometastasis is a clinically distinct subset of metastasis characterized by a limited number of metastases potentially curable with localized therapies. We analyzed pathways targeted by microRNAs over-expressed in clinical oligometastasis samples and identified suppression of cellular adhesion, invasion, and motility pathways in association with the oligometastatic phenotype. We identified miR-127-5p, miR-544a, and miR-655-3p encoded in the 14q32 microRNA cluster as co-regulators of multiple metastatic pathways through repression of shared target genes. These microRNAs suppressed cellular adhesion and invasion and inhibited metastasis development in an animal model of breast cancer lung colonization. Target genes, including TGFBR2 and ROCK2, were key mediators of these effects. Understanding the role of microRNAs expressed in oligometastases may lead to improved identification of and interventions for patients with curable metastatic disease, as well as an improved understanding of the molecular basis of this unique clinical entity.
102 citations
TL;DR: The data indicate that clinically relevant phenotypes of liver metastases can be modeled in vivo, and the growth kinetics and clonogenic frequency of tumor cells colonizing liver is determined.
Abstract: We present a model of hepatic colorectal metastases which represents monoclonal cell lines double-labeled by luciferase and tdTomato. These cells form liver metastasis in varying numbers and patterns similar to those observed in patients. Using in vivo and ex vivo luminescent and fluorescent imaging we determine the growth kinetics and clonogenic frequency of tumor cells colonizing liver. Molecular profiling detected stable expressional differences between clones consistent with their phenotypes. The data indicate that clinically relevant phenotypes of liver metastases can be modeled in vivo.
7 citations
17 Oct 2015
TL;DR: Cancer Principle & Practice of oncology, Cancer Principle and Practice of Oncology as mentioned in this paper, Cancer principle and practice of on cancer, Cancer principle & practice of cancer.
Abstract: Cancer Principle & Practice of oncology , Cancer Principle & Practice of oncology , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
1 citations