Shi-Mao Xia

TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.

TL;DR: It is proposed that these antibodies associate with the viral membrane in a required first step and are thereby poised to capture the transient gp41 fusion intermediate, which bears directly on strategies for rational design of HIV-1 envelope immunogens.

TL;DR: By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, key events are identified in the ontogeny of a V3 -glycan bnAb lineage.

TL;DR: Data provide support for the hypothesis that in some patients, B cells make nonneutralizing cluster II antibodies that may mask or otherwise down-modulate B-cell responses to immunogenic regions of gp41 that could be recognized by B cells capable of producing antibodies like 2F5.

TL;DR: For one of these mAbs, gp41 mAb 7B2, this work provides the first co-crystal structure in complex with a common cyclical loop motif demonstrated to be critical for infection by other retroviruses.