S
Shi-Mao Xia
Researcher at Duke University
Publications - Â 33
Citations - Â 2691
Shi-Mao Xia is an academic researcher from Duke University. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 20, co-authored 31 publications receiving 2361 citations. Previous affiliations of Shi-Mao Xia include Durham University.
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Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
Journal ArticleDOI
Role of HIV membrane in neutralization by two broadly neutralizing antibodies
S. Munir Alam,Marco Morelli,S. Moses Dennison,Hua-Xin Liao,Ruijun Zhang,Shi-Mao Xia,Sophia Rits-Volloch,Li Sun,Stephen C. Harrison,Barton F. Haynes,Bing Chen +10 more
TL;DR: It is proposed that these antibodies associate with the viral membrane in a required first step and are thereby poised to capture the transient gp41 fusion intermediate, which bears directly on strategies for rational design of HIV-1 envelope immunogens.
Journal ArticleDOI
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
Mattia Bonsignori,Mattia Bonsignori,Edward F. Kreider,Daniela Fera,R. Ryan Meyerhoff,R. Ryan Meyerhoff,Todd Bradley,Todd Bradley,Kevin Wiehe,Kevin Wiehe,S. Munir Alam,S. Munir Alam,Baptiste Aussedat,William E. Walkowicz,Kwan-Ki Hwang,Kevin O. Saunders,Kevin O. Saunders,Ruijun Zhang,Morgan A. Gladden,Anthony Monroe,Amit Kumar,Shi-Mao Xia,Melissa Cooper,Mark K. Louder,Krisha McKee,Robert T. Bailer,Brendan W. Pier,Claudia A. Jette,Garnett Kelsoe,Garnett Kelsoe,Wilton B. Williams,Wilton B. Williams,Lynn Morris,John C. Kappes,Kshitij Wagh,Gift Kamanga,Myron S. Cohen,Peter T. Hraber,David C. Montefiori,David C. Montefiori,Ashley M. Trama,Hua-Xin Liao,Hua-Xin Liao,Thomas B. Kepler,M. Anthony Moody,M. Anthony Moody,Feng Gao,Feng Gao,Samuel J. Danishefsky,John R. Mascola,George M. Shaw,Beatrice H. Hahn,Stephen C. Harrison,Bette T. Korber,Barton F. Haynes,Barton F. Haynes +55 more
TL;DR: By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, key events are identified in the ontogeny of a V3 -glycan bnAb lineage.
Journal ArticleDOI
Human Immunodeficiency Virus Type 1 gp41 Antibodies That Mask Membrane Proximal Region Epitopes: Antibody Binding Kinetics, Induction, and Potential for Regulation in Acute Infection
S. Munir Alam,Richard M. Scearce,Robert Parks,Kelly Plonk,Steven G. Plonk,Laura L. Sutherland,Miroslaw K. Gorny,Susan Zolla-Pazner,Stacie Vanleeuwen,M. Anthony Moody,Shi-Mao Xia,David C. Montefiori,Georgia D. Tomaras,Kent J. Weinhold,Salim S. Abdool Karim,Charles B. Hicks,Hua-Xin Liao,James E. Robinson,George M. Shaw,Barton F. Haynes +19 more
TL;DR: Data provide support for the hypothesis that in some patients, B cells make nonneutralizing cluster II antibodies that may mask or otherwise down-modulate B-cell responses to immunogenic regions of gp41 that could be recognized by B cells capable of producing antibodies like 2F5.
Journal ArticleDOI
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques
Sampa Santra,Georgia D. Tomaras,Ranjit Warrier,Nathan I. Nicely,Hua-Xin Liao,Justin Pollara,Pinghuang Liu,S. Munir Alam,Ruijun Zhang,Sarah L. Cocklin,Xiaoying Shen,Ryan Duffy,Shi-Mao Xia,Robert J. Schutte,Charles W. Pemble,S. Moses Dennison,Hui Li,Andrew Chao,Kora Vidnovic,Abbey Evans,Katja Klein,Amit Kumar,James E. Robinson,Gary Landucci,Donald N. Forthal,David C. Montefiori,Jaranit Kaewkungwal,Sorachai Nitayaphan,Punnee Pitisuttithum,Supachai Rerks-Ngarm,Merlin L. Robb,Nelson L. Michael,Jerome H. Kim,Kelly A. Soderberg,Elena E. Giorgi,Lily M. Blair,Bette T. Korber,Christiane Moog,Robin J. Shattock,Norman L. Letvin,Joern E. Schmitz,M. A. Moody,Feng Gao,Guido Ferrari,George M. Shaw,Barton F. Haynes +45 more
TL;DR: For one of these mAbs, gp41 mAb 7B2, this work provides the first co-crystal structure in complex with a common cyclical loop motif demonstrated to be critical for infection by other retroviruses.