Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Maziar Divangahi,Peter Aaby,Shabaana A. Khader,Luis B. Barreiro,Siroon Bekkering,Triantafyllos Chavakis,Reinout van Crevel,Nigel Curtis,Andrew R. DiNardo,Jorge Domínguez-Andrés,Raphael Duivenwoorden,Raphael Duivenwoorden,Stephanie Fanucchi,Zahi A. Fayad,Elaine Fuchs,Melanie Hamon,Kate L. Jeffrey,Nargis Khan,Leo A. B. Joosten,Eva Kaufmann,Eicke Latz,Giuseppe Matarese,Jos W. M. van der Meer,Musa M. Mhlanga,Simone J.C.F.M. Moorlag,Simone J.C.F.M. Moorlag,Willem J. M. Mulder,Willem J. M. Mulder,Shruti Naik,Boris Novakovic,Luke A. J. O'Neill,Jordi Ochando,Keiko Ozato,Niels P. Riksen,Robert W. Sauerwein,Edward R. Sherwood,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Michael H. Sieweke,Michael H. Sieweke,Christine Stabell Benn,Henk Stunnenberg,Joseph C. Sun,Joseph C. Sun,Frank L. van de Veerdonk,Sebastian Weis,David L. Williams,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea,Mihai G. Netea +52 more
TLDR
A common framework is established that describes the experimental standards for defining trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects.Abstract:
The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.read more
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Defining trained immunity and its role in health and disease
Mihai G. Netea,Mihai G. Netea,Jorge Domínguez-Andrés,Luis B. Barreiro,Luis B. Barreiro,Triantafyllos Chavakis,Triantafyllos Chavakis,Maziar Divangahi,Maziar Divangahi,Elaine Fuchs,Leo A. B. Joosten,Jos W. M. van der Meer,Musa M. Mhlanga,Musa M. Mhlanga,Willem J. M. Mulder,Willem J. M. Mulder,Niels P. Riksen,Andreas Schlitzer,Joachim L. Schultze,Christine Stabell Benn,Joseph C. Sun,Joseph C. Sun,Ramnik J. Xavier,Ramnik J. Xavier,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: A group of leaders in the field define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
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