S
Stacey Gabriel
Researcher at Broad Institute
Publications - 411
Citations - 348501
Stacey Gabriel is an academic researcher from Broad Institute. The author has contributed to research in topics: Exome sequencing & Exome. The author has an hindex of 187, co-authored 383 publications receiving 294284 citations. Previous affiliations of Stacey Gabriel include National Institutes of Health & Massachusetts Institute of Technology.
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Journal ArticleDOI
The genetic landscape of high-risk neuroblastoma
Trevor J. Pugh,Olena Morozova,Edward F. Attiyeh,Edward F. Attiyeh,Shahab Asgharzadeh,Shahab Asgharzadeh,Jun S. Wei,Daniel Auclair,Scott L. Carter,Kristian Cibulskis,Megan Hanna,Megan Hanna,Adam Kiezun,Jaegil Kim,Michael S. Lawrence,Lee Lichenstein,Aaron McKenna,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Alex H. Ramos,Alex H. Ramos,Erica Shefler,Andrey Sivachenko,Carrie Sougnez,Chip Stewart,Adrian Ally,Inanc Birol,Readman Chiu,Richard Corbett,Martin Hirst,Shaun D. Jackman,Baljit Kamoh,Alireza Hadj Khodabakshi,Martin Krzywinski,Allan Lo,Richard A. Moore,Karen Mungall,Jenny Q. Qian,Angela Tam,Nina Thiessen,Yongjun Zhao,Kristina A. Cole,Kristina A. Cole,Maura Diamond,Maura Diamond,Sharon J. Diskin,Sharon J. Diskin,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Andrew Wood,Lingyun Ji,Lingyun Ji,Richard Sposto,Richard Sposto,Thomas C. Badgett,Wendy B. London,Yvonne Moyer,Yvonne Moyer,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Malcolm A. Smith,Jaime M. Guidry Auvil,Daniela S. Gerhard,Michael D. Hogarty,Michael D. Hogarty,Steven J.M. Jones,Eric S. Lander,Stacey Gabriel,Gad Getz,Robert C. Seeger,Robert C. Seeger,Javed Khan,Marco A. Marra,Matthew Meyerson,Matthew Meyerson,John M. Maris +76 more
TL;DR: The authors reported a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in high-risk neuroblastoma.
Journal ArticleDOI
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
Wenqing Fu,Timothy D. O’Connor,Goo Jun,Hyun Min Kang,Gonçalo R. Abecasis,Suzanne M. Leal,Stacey Gabriel,Mark J. Rieder,David Altshuler,Jay Shendure,Deborah A. Nickerson,Michael J. Bamshad,Joshua M. Akey +12 more
TL;DR: The results better delimit the historical details of human protein-coding variation, show the profound effect of recent human history on the burden of deleterious SNVs segregating in contemporary populations, and provide important practical information that can be used to prioritize variants in disease-gene discovery.
Journal ArticleDOI
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.
Yujin Hoshida,Sebastian M.B. Nijman,Sebastian M.B. Nijman,Masahiro Kobayashi,Jennifer A. Chan,Jennifer A. Chan,Jean Philippe Brunet,Derek Y. Chiang,Augusto Villanueva,Philippa Newell,Kenji Ikeda,Masaji Hashimoto,Goro Watanabe,Stacey Gabriel,Scott L. Friedman,Hiromitsu Kumada,Josep M. Llovet,Todd R. Golub,Todd R. Golub +18 more
TL;DR: Three robust HCC subclasses are observed, each correlated with clinical parameters such as tumor size, extent of cellular differentiation, and serum alpha-fetoprotein levels, and it is indicated that S1 reflected aberrant activation of the WNT signaling pathway, S2 was characterized by proliferation as well as MYC and AKT activation, and S3 was associated with hepatocyte differentiation.
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
Lili Wang,Michael S. Lawrence,Youzhong Wan,Petar Stojanov,Carrie Sougnez,Kristen E. Stevenson,Lillian Werner,Andrey Sivachenko,David S. DeLuca,Li Zhang,Wandi Zhang,Alexander R. Vartanov,Stacey M. Fernandes,Natalie R. Goldstein,Eric G. Folco,Kristian Cibulskis,Bethany Tesar,Quinlan L. Sievers,Erica Shefler,Stacey Gabriel,Nir Hacohen,Robin Reed,Matthew Meyerson,Todd R. Golub,Eric S. Lander,Donna Neuberg,Jennifer R. Brown,Gad Getz,Catherine J. Wu +28 more
TL;DR: In this article, the authors proposed a method to detect the presence of cancer in the human genome using the Human Genome Research Institute (HGRI) grant U54HG003067.
Journal ArticleDOI
Loss-of-function mutations in APOC3, triglycerides, and coronary disease
Jacy R Crosby,Gina M. Peloso,Gina M. Peloso,Paul L. Auer,David R. Crosslin,Nathan O. Stitziel,Leslie A. Lange,Yingchang Lu,Zheng-Zheng Tang,He Zhang,George Hindy,Nicholas G. D. Masca,Kathleen Stirrups,Stavroula Kanoni,Ron Do,Ron Do,Goo Jun,Youna Hu,Hyun Min Kang,Chenyi Xue,Anuj Goel,Martin Farrall,Stefano Duga,Pier Angelica Merlini,Rosanna Asselta,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Wu Yin,Dermot F. Reilly,Elizabeth K. Speliotes,Caroline S. Fox,Kristian Hveem,Oddgeir L. Holmen,Majid Nikpay,Deborah N. Farlow,Themistocles L. Assimes,Nora Franceschini,Jennifer G. Robinson,Kari E. North,Lisa W. Martin,Mark A. DePristo,Namrata Gupta,Stefan A. Escher,Jan-Håkan Jansson,Natalie R. van Zuydam,Colin N. A. Palmer,Nicholas J. Wareham,Werner Koch,Thomas Meitinger,Annette Peters,Wolfgang Lieb,Raimund Erbel,Inke R. König,Jochen Kruppa,Franziska Degenhardt,Omri Gottesman,Erwin P. Bottinger,Christopher J. O'Donnell,Bruce M. Psaty,Bruce M. Psaty,Christie M. Ballantyne,Christie M. Ballantyne,Gonçalo R. Abecasis,Jose M. Ordovas,Jose M. Ordovas,Olle Melander,Hugh Watkins,Marju Orho-Melander,Diego Ardissino,Ruth J. F. Loos,Ruth McPherson,Cristen J. Willer,Jeanette Erdmann,Alistair S. Hall,Nilesh J. Samani,Panos Deloukas,Panos Deloukas,Panos Deloukas,Heribert Schunkert,James G. Wilson,Charles Kooperberg,Stephen S. Rich,Russell P. Tracy,Danyu Lin,David Altshuler,David Altshuler,Stacey Gabriel,Deborah A. Nickerson,Gail P. Jarvik,L. Adrienne Cupples,L. Adrienne Cupples,Alexander P. Reiner,Alexander P. Reiner,Eric Boerwinkle,Sekar Kathiresan,Sekar Kathiresan +96 more
TL;DR: Rare mutations that disrupt AP OC3 function were associated with lower levels of plasma triglycerides and APOC3, and carriers of these mutations were found to have a reduced risk of coronary heart disease.