Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Thioxothiazolidinone derivatives useful as inhibitors of tdp1
TL;DR: Tdp1 inhibitors of Formula (I) and methods of using those inhibitors to treat cancer are provided in this disclosure as mentioned in this paper, where R1 is hydrogen or lower alkyl and G is a substituted phenyl or optionally substituted heteroaryl group.
Journal ArticleDOI
A Phase I Study of a Combination of Liposomal Irinotecan and Veliparib in Solid Tumors.
Meredith I. LaRose,R. M. Connolly,Ciara C. O’Sullivan,Vamsidhar Velcheti,Rasa Vilimas,Katherine Gano,Susan E. Bates,Yves Pommier,Anish Thomas +8 more
TL;DR: A phase I study was performed to evaluate the safety and tolerability of escalating doses of nal-IRI and the PARP inhibitor veliparib in patients with solid tumors resistant to standard treatments as mentioned in this paper .
Ecteinascidin 743 Interferes with the Activity of EWS-FLI1 in Ewing
Patrick J. Grohar,Laurie B. Griffin,Choh Yeung,Qing-Rong Chen,Yves Pommier,Chand Khanna,Javed Khan,Lee J. Helman +7 more
TL;DR: It is demonstrated that, among a panel of pediatric sarcomas, Ewing sarcoma family of tumors (ESFTs) cell lines bearing the EWS-FLI1 transcription factor are the most sensitive to treatment with ET-743 compared with osteosarcoma, rhabdomyosar coma, and synovial sarcomA.
Journal ArticleDOI
Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions.
Franciele Faccio Busatto,Sofiane Y. Mersaoui,Yilun Sun,Yves Pommier,Jean-Yves Masson,Jenifer Saffi,Jenifer Saffi +6 more
TL;DR: In this paper, the authors further defined the mechanism and type of lesions induced by TOP2 inhibitors when Cockayne Syndrome B (CSB) is abrogated and observed that CSB knockdown provokes the accumulation of double-strand break (DSB) induced by topoisomerase inhibitors.