Yves Pommier

TL;DR: A line of Chinese hamster cells characterized the resistance of which to the cytotoxic effect of intercalators and etoposide is associated with a reduced formation of protein-associated DNA strand breaks, and had an unusually high level of DNA linking activity in the absence of 4'-(9-acridinylamino)methanesulfon-m-anisidide.

TL;DR: Topoisomerase I (top1) inhibitors (camptothecins and other structurally diverse compounds) are effective and promising anticancer agents and determinants of selectivity toward cancer cells and resistance are multifactorial.

TL;DR: P phenotypic changes associated with TPA-induced differentiation include inactivation of a cytoplasmic activity that can induce DNA fragmentation associated with apoptosis, which is similar to drug-induced DNA fragmentation.

TL;DR: Among 97 doxorubicin-stabilized sites that were localized at the DNA sequence level, none coincided with any of the 90 topoisomerase II cleavage sites detected in the same regions in the absence of drug, explaining the mutual exclusivity of the two classes of sites.

TL;DR: Data show that the DSB induced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and 5-iminodaunorubicin at DNA topoisomerase II binding sites correlated closely with SCE, mutations, and cell killing and could therefore be responsible for their production.