Yves Pommier

TL;DR: The hypothesis that there is a conserved negative transcription regulator within intron 1 of the TOP1 gene associated with a quadruplex-prone region is suggested.

TL;DR: Both the N- and C-terminal domains of integrase contributed to efficient DNA binding, and mutation of Lys-136 significantly reduced Schiff base formation, implicating this residue in viral DNA binding.

TL;DR: It is demonstrated that mitochondrial DNA displays increased negative supercoiling in TOP1mt knockout cells and murine tissues, and the presence of Top2α-DNA complexes in the mtDNA D-loop region, at the sites where both ends of 7S DNA are positioned, suggests a structural role for Top2 in addition to its classical topoisomerase activities.

TL;DR: Internucleosomal DNA fragmentation was also identified in HL-60 cells induced to differentiate by sodium butyrate and dimethylsulfoxide treatment, suggesting that apoptosis could be the common mode of death of terminally differentiated HL- 60 cells.

TL;DR: It is reported here that DNA adducts formed from benzo[a]pyrene bay-region diol epoxides can markedly affect top1 activity, and the trans opened adduct from the highly carcinogenic (+)-diol epoxide is the most active in inducing top1 cleavage independently of camptothecin, demonstrating that minor groove alkylation can efficiently poison top1.