Yves Pommier

TL;DR: In this article, the effect of ET-743 on the Ewing sarcoma family of tumors (ESFTs) has been investigated and it has been shown that EWS-FLI1-based cell lines are more sensitive to treatment compared with other tumor types.

TL;DR: This review largely summarizes work presented at the Third Biennial IASLC Small Cell Lung Cancer Meeting and identifies key knowledge gaps that should be addressed in order to advance the field in pursuit of reduced small cell lung cancer mortality.

TL;DR: There are now several inhibitors with known sites of actions and antiviral activity, the challenge is to convert these leads into drugs that will selectively target integrase in vivo, and can be added to the antiviral armamentarium.

TL;DR: The G-tetrad-forming oligonucleotides T30177 and T30695 have been identified as potent inhibitors of human immunodeficiency virus type 1 integrase activity and docking results show a high probability of interaction between the GTGT loop residues of the G-quartet inhibitors and the catalytic site of HIV-1 IN, in agreement with the experimental observation.

TL;DR: An update on the IN inhibitors reported in the last two years, including second generation STI, recently developed hydroxylated aromatics, natural products, peptide, antibody and oligonucleotide inhibitors, and the targeting of IN cofactors such as LEDGF and Vpr will be discussed as novel strategies for the treatment of AIDS.