Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
Papers
More filters
Journal ArticleDOI
Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline.
TL;DR: The indenoisoquinolines are a novel class of cytotoxic non-camptothecin topoisomerase I inhibitors and it was found unexpectedly that an alkenyl substituent on the C11 position was autoxidatively cleaved under basic conditions to afford a ketone.
Journal ArticleDOI
Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft.
Bradley R. Kossmann,Monica Abdelmalak,Sophia Lopez,Gabrielle S. Tender,Chunli Yan,Yves Pommier,Christophe Marchand,Ivaylo Ivanov +7 more
TL;DR: Virtual screening of the NCI diversity small molecule database and MM-PBSA per-residue energy decomposition identified important interactions of the compounds with specific TDP2 residues, which could provide new avenues for synthetic optimization of these scaffolds.
Journal ArticleDOI
Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3'-processing and choice of nucleophile by HIV-1 integrase.
TL;DR: The results in this study suggest that 'mutagenesis' of the DNA backbone can also alter the choice of nucleophile in the 3'-processing reaction.
Journal ArticleDOI
Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents.
Guozhang Xu,Arunachalam Kannan,Tracy L. Hartman,Heather Wargo,Karen M. Watson,Jim A. Turpin,Robert W. Buckheit,Allison A. Johnson,Yves Pommier,Mark Cushman +9 more
TL;DR: Attempts to verify inhibition of virus attachment and fusion as antiviral targets using time-of-addition experiments failed to confirm these observations, and instead identified an antiviral target occurring after completion of reverse transcription.
Journal ArticleDOI
Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines.
Barry R. Zeeberg,William C. Reinhold,René Snajder,Gerhard G. Thallinger,John N. Weinstein,Kurt W. Kohn,Yves Pommier +6 more
TL;DR: Clusters of coregulated genes that are associated with functional groupings of GO biological process categories reflect cancer-related themes such as adhesion, cell migration, RNA splicing, immune response and signal transduction demonstrate transcriptional coregulation of functionally-related genes.