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Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Journal ArticleDOI
Streptonigrin-Induced Topoisomerase II Sites Exhibit Base Preferences in the Middle of the Enzyme Stagger
TL;DR: Preference for bases not immediately flanking the cleavage sites has not been reported previously and indicates that a mechanism other than "drug stacking" within the DNA break is taking place with streptonigrin to stabilize cleavable complexes.
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Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo
Jang-Eun Cho,Shar-yin N. Huang,Peter M. J. Burgers,Stewart Shuman,Yves Pommier,Sue Jinks-Robertson +5 more
TL;DR: The data fortify sequential Top1 cleavage as the mechanism for ribonucleotide-dependent deletions and provide new insight into the component steps of this process.
Journal ArticleDOI
Recognition and inhibition of HIV integrase by a novel dinucleotide.
TL;DR: A conceptually novel dinucleotide is discovered, pIsodApdC, which is a potent inhibitor of this key viral enzyme, HIV-1 integrase, in the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond.
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Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2).
Le-Mao Yu,Zhu Hu,Yu Chen,Azhar Ravji,Sophia Lopez,Caroline B. Plescia,Qian Yu,Hui Yang,Monica Abdelmalak,Sourav Saha,Keli Agama,Evgeny Kiselev,Christophe Marchand,Yves Pommier,Lin-Kun An +14 more
TL;DR: The discovery of the furoquinolinedione chemotype is reported as a suitable skeleton for the development of selective TDP2 inhibitors at low-micromolar range.
Journal ArticleDOI
Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors.
Mark Cushman,Muthusamy Jayaraman,Jeffrey A. Vroman,Anna K. Fukunaga,Brian M. Fox,Glenda Kohlhagen,Dirk Strumberg,Yves Pommier +7 more
TL;DR: In this paper, a new series of indenoisoquinolines was prepared and tested for cytotoxicity in human cancer cell cultures and for activity against topoisomerase I. The synthesis relied on the condensation of substituted Schiff bases with homophthalic anhydrides.