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Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer.
Jayakumar Nair,Tzu-Ting Huang,Junko Murai,Brittany Haynes,Patricia S. Steeg,Yves Pommier,Jung-Min Lee +6 more
TL;DR: It is reported that BRCAwt HGSOC develops resistance to prexasertib monotherapy via a prolonged G2 delay induced by lower CDK1/CyclinB1 activity, thus preventing cells from mitotic catastrophe and cell death, and highlighting a potential combination treatment approach to overcome CHK1i resistance.
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Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
Xue Zhi Zhao,Kasthuraiah Maddali,Mathieu Métifiot,Steven J. Smith,B. Christie Vu,Christophe Marchand,Stephen H. Hughes,Yves Pommier,Terrence R. Burke +8 more
TL;DR: Bicycleic hydroxy‐1H‐pyrrolopyridine‐triones are reported as a new family of HIV‐1 integrase inhibitors that were efficiently prepared using a key ‘Pummerer cyclization deprotonation cycloaddition’ cascade of imidosulfoxides.
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Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA
Ilaria Dalla Rosa,Steffi Goffart,Melanie Wurm,Constanze Wiek,Frank Essmann,Stefan Sobek,Peter Schroeder,Hongliang Zhang,Jean Krutmann,Helmut Hanenberg,Klaus Schulze-Osthoff,Christian Mielke,Yves Pommier,Fritz Boege,Morten O. Christensen +14 more
TL;DR: It is proposed that adaptation of this domain to different chromatin environments in nuclei and mitochondria has driven evolutional development and conservation of organelle-restricted topoisomerase I paralogs in vertebrates.
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Lasonolide A, a potent and reversible inducer of chromosome condensation
TL;DR: It is revealed that LSA induces rapid and reversible premature chromosome condensation (PCC) associated with cell detachment, plasma membrane smoothening and actin reorganization, and the profound epigenetic alterations induced by LSA are demonstrated.
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TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.
Muthana Al Abo,Hiroyuki Sasanuma,Xiaojun Liu,Vinodh N. Rajapakse,Shar yin Huang,Evgeny Kiselev,Shunichi Takeda,William Plunkett,Yves Pommier +8 more
TL;DR: The importance of TDP1 is identified as a novel determinant of response to CNDAC across various cancer types (especially non–small cell lung cancers), and the differential involvement of BRCA2, PARP1, and T DP1 in the cellular responses to C NDAC, AraC, and CPT is demonstrated.