Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase
Jing Tang,Kasthuraiah Maddali,Mathieu Métifiot,Yuk Y. Sham,Robert Vince,Yves Pommier,Zhengqiang Wang +6 more
TL;DR: These studies support an antiviral mechanism of dual inhibition against both IN and RT and validate 3-hydroxypyrimidine-2,4-diones as an IN inhibitor scaffold.
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Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors
TL;DR: Despite an imperfect correlation between cytotoxicities and topoisomerase I inhibition results, the hypothetical structural model of the cleavage complex presented here provides a conceptual framework to explain the structure-activity relationships.
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Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2)
Jayakanth Kankanala,Christophe Marchand,Monica Abdelmalak,Hideki Aihara,Yves Pommier,Zhengqiang Wang +5 more
TL;DR: The discovery of isoquinoline-1,3-dione as a viable chemotype for selectively inhibiting TDP2 may provide a platform toward understanding TDP1 as a drug target.
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Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis.
Akira Yoshida,Yoshimasa Urasaki,Mark Waltham,Ann Charlotte Bergman,Philippe Pourquier,Dominic G. Rothwell,Manabu Inuzuka,John N. Weinstein,Takanori Ueda,Ettore Appella,Ian D. Hickson,Yves Pommier +11 more
TL;DR: It is found that Ape1 itself preferentially cleaves damaged chromatin DNA isolated from cells treated with apoptotic stimuli and that silencing of Ape 1 expression decreases apoptotic DNA fragmentation in DFF40/CAD-deficient cells.
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Effects of DNA methylation on topoisomerase I and II cleavage activities.
TL;DR: Results suggest an interaction of topoisomerase I with the DNA major grove at positions -3 and -4, which may have profound effects on the activity ofTopoisomerases and may alter the distribution of cleavage sites produced by anticancer drugs in chromatin.