Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
Papers
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Journal ArticleDOI
The Immunotherapy Landscape in Adrenocortical Cancer.
Guillaume Joe Pegna,Nitin Roper,Rosandra N. Kaplan,Emily K. Bergsland,Katja Kiseljak-Vassiliades,Mouhammed Amir Habra,Yves Pommier,Jaydira Del Rivero +7 more
TL;DR: A broad array of immune-activating and immune-modulating antineoplastic agents have demonstrated clinical benefit in a wide range of solid and hematologic malignancies.
Journal ArticleDOI
Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states
Diane T. Takahashi,Danièle Gadelle,Keli Agama,Evgeny Kiselev,Hongliang Zhang,Emilie Yab,Stéphanie Petrella,Patrick Forterre,Yves Pommier,Claudine Mayer +9 more
TL;DR: In this article , the authors solved the three-dimensional structure of TOP1 in the absence of DNA, and identified a highly conserved tyrosine near the hinge as mediating the transition from the open to closed conformation upon DNA binding.
Journal ArticleDOI
Virtual screening using ligand-based pharmacophores for inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1)
Iwona E. Weidlich,Thomas S. Dexheimer,Christophe Marchand,Smitha Antony,Yves Pommier,Marc C. Nicklaus +5 more
TL;DR: 46 compounds matching the three-dimensional arrangement of the pharmacophoric features of hTdp1 inhibitors are presented and discussed in some detail, some of which may provide new scaffolds for developing inhibitors of Tdp1.
Journal ArticleDOI
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin
TL;DR: The results indicate that brostallicin induces DNA double-strand breaks and suggest γ-H2AX as a pharmacodynamic biomarker for broStallicin.
Book ChapterDOI
Topoisomerase-Induced DNA Damage
Yves Pommier,Neil Osheroff +1 more
TL;DR: This brief chapter gives an overview of the broad range of lesions that lead to the accumulation of cleavage complexes produced by DNA topoisomerases I and II.