Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
Papers
More filters
Journal ArticleDOI
Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction
Giordano Mancini,Ilda D'Annessa,Andrea Coletta,Giovanni Chillemi,Yves Pommier,Mark Cushman,Alessandro Desideri +6 more
TL;DR: The analyses demonstrated the role of the drug in conformationally stabilizing the protein-DNA interaction and the indenoisoquinoline keeps Lys532 far from the DNA, making it unable to participate in the religation reaction, indicating that both short- and long-range interactions contribute to the drug poisoning effect.
Journal ArticleDOI
DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
Sourav Saha,Yilun Sun,Shar-yin Naomi Huang,Simone A Baechler,Lorinc Pongor,Keli Agama,Ukhyun Jo,Hongliang Zhang,Yuk-Ching Tse-Dinh,Yves Pommier +9 more
TL;DR: In this paper, a self-trapping mutant of TOP3B (R338W-TOP3B) was found to induce R-loops, genomic damage, and growth defect.
Journal ArticleDOI
Phenanthriplatin Acts As a Covalent Poison of Topoisomerase II Cleavage Complexes
TL;DR: The observation that phenanthriplatin can act as a Top2 poison highlights opportunities to design nonclassical platinum anticancer agents with this novel mechanism of action.
Journal ArticleDOI
Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription.
TL;DR: It is proposed that the long noncoding RNA species in the D-loop region are generated by the extension of H-strand transcripts beyond their canonical stop site and that TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D- loop formation.
Journal ArticleDOI
Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins.
TL;DR: Interfacial inhibition, a molecular mechanism of action for a wide variety of natural products including TOP2 inhibitors, rapamycin, tubulin inhibitors and anesthetic drugs, is proposed.