Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Journal Article
Characterization of a Novel Topoisomerase I Mutation from a Camptothecin-resistant Human Prostate Cancer Cell Line
Yoshimasa Urasaki,Gary S. Laco,Phillipe Pourquier,Yuji Takebayashi,Glenda Kohlhagen,Christopher Gioffre,Hongliang Zhang,Devasis Chatterjee,Panayotis Pantazis,Yves Pommier +9 more
TL;DR: The structure and function of topoisomerase I (top1) protein in the camptothecin (CPT)-resistant prostate cancer cell lines is characterized and it is found that the R364H mutant top1 was CPT resistant and fully active.
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Arylamide inhibitors of HIV-1 integrase
TL;DR: Based on data derived from a large number of HIV-1 integrase inhibitors, similar structural features can be observed, which consist of two aryl units separated by a central linker, evidence that the monomeric 6,7- and 5,6-dihydroxynaphthalenes may be interacting with the enzyme in markedly different fashions is provided.
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Potent Inhibitors of Human Immunodeficiency Virus Type 1 Integrase: Identification of a Novel Four-Point Pharmacophore and Tetracyclines as Novel Inhibitors
TL;DR: Remarkable potency against the IN in the absence of divalent metals and the core enzyme coupled with water solubility makes tetracyclines potential candidates for X-ray crystal structure determination with IN.
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MGMT Status as a Clinical Biomarker in Glioblastoma.
Madison Butler,Lorinc Pongor,Yu-Ting Su,Liqiang Xi,Mark Raffeld,Martha Quezado,Jane B. Trepel,Kenneth Aldape,Yves Pommier,Jing Wu +9 more
TL;DR: The discordance between MGMT methylation, expression, and patient outcome, which currently challenges the implementation of this biomarker in clinical practice is elucidated.
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Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.
TL;DR: Chinese hamster top 1 protein with a Gly505-->Ser mutation that was expressed in bacteria was resistant to CPT, indicating that this single base mutation is involved in CPT resistance.