Yves Pommier

TL;DR: Because these results were reproduced in experiments using DNA topoisomerase II isolated from L1210 nuclei, it is likely that the intercalator-induced protein-associated DNA breaks detected by alkaline elution in nuclei representDNA topoisomersase II-DNA complexes.

TL;DR: The DNA unwinding effects of some 9-aminoacridine derivatives were compared under reaction conditions that could be used to study drug-induced topoisomerase II inhibition and led to the definition of a drug intrinsic unwinding constant (k).

TL;DR: An update on integrase inhibitors reported in the last two years, including two novel inhibitors in early clinical trials, recently developed hydroxylated aromatics, natural products, peptide, antibody and oligonucleotide inhibitors, and the proposed mechanism of diketo acid inhibition are reviewed.

TL;DR: It is found that indolicidin interferes with formation of the catalytic integrase-DNA complex by directly binding DNA and that multiple actions at the level of DNA might be a common property of antimicrobial peptides.

TL;DR: One of the monoamine analogues, which features a bis(2-hydroxyethyl)amino group in the side chain, proved to be one of the most cytotoxic indenoisoquinoline synthesized to date, with a GI50 mean-graph midpoint of 0.07 microM in the NIH human cancer cell culture screen, and topoisomerase I inhibitory activity comparable to that of camptothecin.