Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Journal Article
Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.
Abhijit Mazumder,Nouri Neamati,Jean Pierre Sommadossi,Gilles Gosselin,Raymond F. Schinazi,Jean Louis Imbach,Yves Pommier +6 more
TL;DR: The active nucleotides tested inhibited binding of HIV-1 integrase to its substrate DNA an inhibited an integrase deletion mutant containing only amino acids 50-212, indicating that nucleotide bind to the enzyme catalytic core.
Journal ArticleDOI
Multifactorial Regulation of E-Cadherin Expression: An Integrative Study
William C. Reinhold,Mark Reimers,Mark Reimers,Philip L. Lorenzi,Philip L. Lorenzi,Jennifer C. Ho,Uma Shankavaram,Micah S. Ziegler,Kimberly J. Bussey,Kimberly J. Bussey,Satoshi Nishizuka,Satoshi Nishizuka,Ogechi Ikediobi,Ogechi Ikediobi,Yves Pommier,John N. Weinstein +15 more
TL;DR: Levels of cellular E-cad expression are associated with levels of cell-cell adhesion and response to drug treatment, and Predictions of E- cad regulation based on the above factors were tested and verified by demethylation studies.
Journal ArticleDOI
Identification of a nucleotide binding site in HIV-1 integrase
Richard R. Drake,Nouri Neamati,Huixiao Hong,André A. Pilon,Prasanna Sunthankar,Steven D. Hume,George W. A. Milne,Yves Pommier +7 more
TL;DR: This report elucidates the binding site of a nucleotide inhibitor of HIV-1 integrase, and possibly a component of the enzyme polynucleotide binding site.
Journal ArticleDOI
Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity
Fabricio G. Sousa,Renata Matuo,Sai-Wen Tang,Vinodh N. Rajapakse,Augustin Luna,Chris Sander,Sudhir Varma,Paul Simon,James H. Doroshow,William C. Reinhold,Yves Pommier +10 more
TL;DR: New rational uses for existing anticancer drugs are proposed based on a comprehensive analysis of DNAR genomic parameters, including the Fanconi anemia-scaffolding gene SLX4, which stood out among the genes most significantly related with DNA synthesis and topoisomerase inhibitors.
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Genomic and evolutionary classification of lung cancer in never smokers
Tongwu Zhang,Philippe Joubert,Naser Ansari-Pour,Wei Zhao,Phuc H Hoang,Rachel Lokanga,Aaron L Moye,Jennifer Rosenbaum,Abel Gonzalez-Perez,Francisco Martínez-Jiménez,Andrea Castro,Lucia Anna Muscarella,Paul Hofman,Dario Consonni,Angela Cecilia Pesatori,Michael Kebede,Mengying Li,Bonnie E. Gould Rothberg,Iliana Peneva,Iliana Peneva,Matthew B. Schabath,Maria Luana Poeta,Manuela Costantini,Daniela Hirsch,Kerstin Heselmeyer-Haddad,Amy Hutchinson,Mary E. Olanich,Scott M. Lawrence,Petra Lenz,Máire A. Duggan,Praphulla M S Bhawsar,Jian Sang,Jung Kim,Laura Mendoza,Natalie Saini,Leszek J. Klimczak,S M Ashiqul Islam,Burcak Otlu,Azhar Khandekar,Nathan Cole,Douglas R. Stewart,Jiyeon Choi,Kevin M. Brown,Neil E. Caporaso,Samuel H. Wilson,Yves Pommier,Qing Lan,Nathaniel Rothman,Jonas S Almeida,Hannah Carter,Thomas Ried,Carla F. Kim,Carla F. Kim,Nuria Lopez-Bigas,Montserrat Garcia-Closas,Jianxin Shi,Yohan Bossé,Bin Zhu,Dmitry A. Gordenin,Ludmil B. Alexandrov,Stephen J. Chanock,David C. Wedge,David C. Wedge,Maria Teresa Landi +63 more
TL;DR: In this paper, a high-coverage whole-genome sequencing of 232 lung cancer in never smokers (LCINS) showed three subtypes defined by copy number aberrations.