Yves Pommier

TL;DR: A hydroxyethylaminopropyl side chain on the lactam nitrogen of two halogenated indenoisoquinoline Top1 inhibitors was found to also impart inhibitory activity against tyrosyl DNA phosphodiesterases 1 and 2 (TDP1 and TDP2), which are enzymes that participate in the repair of DNA damage induced by Top1 poisons.

TL;DR: The most recent advances in the field of genetics are presented, including the new genetic insights of PPGLs and the latest guidelines on the surveillance of asymptomatic SDHx mutation carriers.

TL;DR: It was underlined that cross-resistance to the new indenoisoquinoline drugs depends on the specific underlying molecular mechanism of resistance to SN-38, and it was added to the growing knowledge about resistance mechanisms for Top1-targeting chemotherapeutic drugs.

TL;DR: 3-aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione emerge as a new prospective chemotype for the search of antitumor agents.

TL;DR: Eight novel series of A-ring-substituted aromathecins are synthesized, through a simple, modular route, as part of a comprehensive SAR study, and this considerable SAR overlap lends further support to the hypothesis that aromathcins bind in the Top1 cleavage complex as interfacial inhibitors in a 'camptothecin-like' pose.