Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
Papers
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Journal ArticleDOI
Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.
John K. Buolamwini,Krishnamchari Raghavan,Mark R. Fesen,Yves Pommier,Kurt W. Kohn,John N. Weinstein +5 more
TL;DR: E-state indices at C6, C3′, C5′,C5, and O4 were found to be more important for prediction of activity than those for any of the other 12 flavone skeletal atoms that are common to the molecules in the data set.
Patent
Topoisomerase ii inhibitors and therapeutic uses therefor
TL;DR: Azatoxin and derivatives of it are illustrative of a new class of antitumor drugs that are topoisomerase II (top 2) inhibitors as mentioned in this paper, and they induce numerous doublestrand breaks according to a cleavage pattern which differs from those of known top 2 inhibitors.
Journal ArticleDOI
Characterization of mismatch and high-signal intensity probes associated with Affymetrix genechips
TL;DR: The data suggests that MM intensity from PM signal can be a major source of error analysis, leading to fewer potentially biologically important candidate genes.
Journal ArticleDOI
Design and synthesis of dimeric HIV-1 integrase inhibitory peptides
TL;DR: Dimers of known HIV-1 integrase inhibitory hexapeptide H-His-Cys-Lys-Phe-Trp-trp-NH(2) containing different lengths of cross linkers in the place of cysteine residue, were designed, and synthesized.
Journal ArticleDOI
Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.
David J. Adams,Mateus Webba da Silva,James L. Flowers,Glenda Kohlhagen,Yves Pommier,O. Michael Colvin,Govindarajan Manikumar,Mansukh C. Wani +7 more
TL;DR: Increasing 7-alkyl chain length in six of the ten-substituted CPTs enhanced potency, which was directly correlated with persistence of topoisomerase I-induced DNA cleavage complexes in 10-hydroxy, 10-methoxy, and 10,11-methylenedioxy substituted C PTs.