Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Journal ArticleDOI
CellMiner: a relational database and query tool for the NCI-60 cancer cell lines
Uma Shankavaram,Sudhir Varma,David W. Kane,Margot Sunshine,Krishna K. Chary,William C. Reinhold,Yves Pommier,John N. Weinstein,John N. Weinstein +8 more
TL;DR: CellMiner is a relational database tool for storing, querying, integrating, and downloading molecular profile data on the NCI-60 and other cancer cell types and provides a template to use in providing such functionality for other Molecular profile data generated by academic institutions, public projects, or the private sector.
Book ChapterDOI
Repair of topoisomerase I-mediated DNA damage.
Yves Pommier,Juana M. Barcelo,Juana M. Barcelo,V. Ashutosh Rao,V. Ashutosh Rao,Olivier Sordet,Olivier Sordet,Andrew Jobson,Andrew Jobson,Laurent Thibaut,Laurent Thibaut,Ze-Hong Miao,Ze-Hong Miao,Jennifer A. Seiler,Jennifer A. Seiler,Hongliang Zhang,Hongliang Zhang,Christophe Marchand,Christophe Marchand,Keli Agama,Keli Agama,John L. Nitiss,John L. Nitiss,Christophe E. Redon,Christophe E. Redon +24 more
TL;DR: This chapter reviews the developments in several pathways involved in the repair of Top1 cleavage complexes and the role of Chk1 and Chk2 checkpoint kinases in the cellular responses to Top1 inhibitors.
Journal Article
Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.
TL;DR: Exposure to breast carcinoma MCF-7 or cervical carcinoma HeLa cells to anticancer agents resulted in a 4-5-fold increased survivin expression and sequential ablation of p34(cdc2) kinase activity may remove the survivin viability checkpoint and enhance apoptosis in tumor cells.
Journal Article
Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.
TL;DR: The hypothesis that DNA single-strand breaks and DNA-protein cross-links induced by camptothecin in mammalian cells are due to an action on topoisomerase I is supported.
Journal ArticleDOI
Cleaving the Oxidative Repair Protein Ape1 Enhances Cell Death Mediated by Granzyme A
Zusen Fan,Paul J. Beresford,Dong Zhang,Zhan Xu,Carl D. Novina,Akira Yoshida,Yves Pommier,Judy Lieberman +7 more
TL;DR: The rate-limiting enzyme of DNA base excision repair, apurinic endonuclease-1 (Ape1), binds to GzmA and is contained in the SET complex, a macromolecular complex of 270–420 kDa that is associated with the endoplasmic reticulum and is targeted by GzAMA during cell-mediated death.